PMID: 11321234Apr 26, 2001Paper

Fas-FasL in Hashimoto's thyroiditis

Journal of Clinical Immunology
G StassiR De Maria

Abstract

Hashimoto's thyroiditis is a common chronic autoimmune disease characterized by the loss of thyroid follicular cells (thyrocytes) that are gradually replaced by lymphocytic infiltration and diffuse fibrosis. These morphological findings suggested that autoreactive T-cell clones were responsible for thyrocyte destruction and hypothyroidism through effector-target cytotoxic recognition. Later, autonomous interaction between thyrocyte Fas and FasL has been proposed as a major mechanism of thyrocyte depletion in Hashimoto's thyroiditis. Here, we analyze the possible role of Fas and FasL in the pathogenesis of Hashimoto's thyroiditis. We suggest that the Fas-FasL system dictates the outcome of the autoimmune response by acting on both immune and target cells.

Citations

May 23, 2015·Journal of Immunology Research·Aleksandra PyzikJacek Roliński
Nov 26, 2004·Molecular Endocrinology·Emese MezosiJames R Baker
Dec 14, 2004·Thyroid : Official Journal of the American Thyroid Association·Yukiyo NakamuraYoshinori Iwatani
Nov 28, 2002·Proceedings of the National Academy of Sciences of the United States of America·Michael J PinkoskiDouglas R Green
Oct 3, 2012·The Journal of Endocrinology·Marcella SalzanoMario Vitale
May 8, 2003·Journal of the American Academy of Dermatology·Julia AiWarren R Heymann

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