Fas gene promoter -670 polymorphism in gynecological cancer

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
M UedaM Ueki

Abstract

Single-nucleotide polymorphism at -670 of Fas gene promoter (A/G) was examined in a total of 354 blood samples from normal healthy women and gynecological cancer patients. They consisted of 95 normal, 83 cervical, 108 endometrial, and 68 ovarian cancer cases. Eighty-three patients with cervical cancer had statistically higher frequency of GG genotype and G allele than 95 controls (P= 0.0353 and 0.0278, respectively). There was no significant difference in the genotype or allele prevalence between control subjects and endometrial or ovarian cancer patients. The Fas -670 GG genotype was associated with an increased risk for the development of cervical cancer (OR = 2.56, 95% CI = 1.08-6.10) compared with the AA genotype. The G allele also increased the risk of cervical cancer (OR = 1.60, 95% CI = 1.05-2.43) compared with the A allele. Germ-line polymorphism of Fas gene promoter -670 may be associated with the risk of cervical cancer in a Japanese population.

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Citations

Jun 22, 2006·Journal of Cancer Research and Clinical Oncology·Elaine Cristina MorariLaura Sterian Ward
Aug 1, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jian Shen, Ning-Xia Sun
Aug 2, 2007·Prostate Cancer and Prostatic Diseases·L LimaR Medeiros
May 27, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Dapeng LeiGuojun Li
Feb 5, 2008·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Chi-Shing Cho
Oct 12, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yan ZhangLi Wei
Aug 3, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Tao LiuChuize Kong
Dec 11, 2008·Human Cell·Masatsugu UedaSadamu Noda
Oct 4, 2006·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Sun Ha ParkJae Yong Park
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May 16, 2015·International Journal of Cancer. Journal International Du Cancer·Fenghua ZhangGuojun Li
Dec 5, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Sateesh Reddy NallapalleV T S Vidudala Prasad
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Aug 6, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Shing Cheng Tan, Ravindran Ankathil

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