Fas-induced programmed cell death is mediated by a Ras-regulated O2- synthesis

Immunology
E GulbinsF Lang

Abstract

Fas induces apoptosis in lymphocytes via a poorly defined intracellular signalling cascade. Previously, we have demonstrated the involvement and significance of a signalling cascade from the Fas receptor via sphingomyelinases and ceramide to Ras in Fas-induced apoptosis. Here we demonstrate rapid and transient synthesis of reactive oxygen intermediates (ROI) via activation of Ras after Fas. Genetic inhibition of Ras by transfection of transdominant inhibitory N17Ras blocked Fas-mediated ROI synthesis and programmed cell death. Likewise, the antioxidants N-acetyl-cysteine and N-t-butyl-phenylnitrone abolished Fas-induced cell death, pointing to an important role for Ras-triggered ROI synthesis in Fas-mediated programmed cell death.

References

Apr 3, 1992·Science·D P CerrettiL A Cannizzaro
Apr 3, 1992·Cell·G I EvanD C Hancock
Feb 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·T Ochi, P A Cerutti
Oct 22, 1993·Cell·D M HockenberyS J Korsmeyer
Oct 1, 1994·The Journal of Experimental Medicine·M G CifoneR Testi
Jan 1, 1995·Immunology Today·S Nagata, T Suda
Apr 27, 1995·Nature·M D Jacobson, M C Raff
Mar 30, 1995·Nature·R G QiuM Symons
Apr 27, 1995·Nature·S ShimizuY Tsujimoto
Aug 2, 1994·Proceedings of the National Academy of Sciences of the United States of America·M Mayer, M Noble
Feb 25, 1994·Science·L ShiA H Greenberg
Apr 29, 1994·Science·B Beutler, C van Huffel
Dec 16, 1993·Nature·M S Boguski, F McCormick
Mar 19, 1993·Science·L M ObeidY A Hannun
Mar 1, 1993·Immunology Today·J J Cohen
May 1, 1996·European Journal of Immunology·T ChibaK Kikuchi
Mar 1, 1996·Trends in Biochemical Sciences·M D Jacobson

❮ Previous
Next ❯

Citations

Jan 31, 2002·Arthritis and Rheumatism·Peter GergelyAndras Perl
Aug 12, 1998·BioFactors·M B Hampton, S Orrenius
Feb 18, 1999·Toxicology Letters·M B Hampton, S Orrenius
Feb 28, 2002·Free Radical Biology & Medicine·Mauro ProvincialiGiovanni Bernardini
Apr 30, 1998·Current Opinion in Cell Biology·T Finkel
Apr 5, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Erich Gulbins
Jun 14, 2003·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Barbara WirleitnerDietmar Fuchs
Aug 29, 2007·The Journal of Biological Chemistry·Rodrigo FrancoJohn A Cidlowski
Oct 23, 2008·The Journal of Biological Chemistry·Rodrigo FrancoJohn A Cidlowski
Sep 7, 2002·Antioxidants & Redox Signaling·Andras PerlKatalin Banki
Feb 28, 2001·Antioxidants & Redox Signaling·J F Engelhardt
Feb 12, 2005·Antioxidants & Redox Signaling·Mehdi ShakibaeiBharat B Aggarwal
Dec 11, 2008·The Journal of Pharmacology and Experimental Therapeutics·Jianli NiuPappachan E Kolattukudy
Oct 3, 2003·The Journal of Clinical Investigation·Sanae HagaMichitaka Ozaki
Jun 13, 1998·The Journal of Clinical Investigation·K S KimT Finkel
Jan 5, 2011·Frontiers in Bioscience (Landmark Edition)·Jean H Overmeyer, William A Maltese
Apr 12, 2000·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·F C Luft
Dec 24, 1996·Proceedings of the National Academy of Sciences of the United States of America·B BrennerF Lang
Jun 19, 2004·International Reviews of Immunology·Andras PerlKatalin Banki
Dec 26, 2007·Archives of Physiology and Biochemistry·R FrancoM I Panayiotidis
Nov 16, 2002·The Journal of Physiology·Tom SchillingClaudia Eder
Sep 16, 2004·Journal of Cellular Physiology·Djordje MedanYon Rojanasakul
Jul 14, 2001·Redox Report : Communications in Free Radical Research·R J Carmody, T G Cotter
Jan 10, 2002·Audiology : Official Organ of the International Society of Audiology·L BertolasoM Previati
Jul 18, 1997·Biochemical and Biophysical Research Communications·E GulbinsF Lang
Feb 2, 2010·Biochimica Et Biophysica Acta·Erich GulbinsIldikò Szabò
Sep 11, 2002·The Journal of Biological Chemistry·Valerie GouazeThierry Levade
Aug 15, 2002·American Journal of Physiology. Cell Physiology·Bin LuYon Rojanasakul
Mar 8, 2003·Blood·Isabel Perez-CruzDavid W Golde
Nov 30, 2000·The Journal of Biological Chemistry·F ParisR Kolesnick
Apr 10, 2003·American Journal of Physiology. Renal Physiology·Kazuhiko TsuruyaMitsuo Iida
Feb 11, 1998·Physiological Reviews·F LangD Häussinger
Feb 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Liying WangYon Rojanasakul
Aug 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Satoshi OkadaAlan M Krensky
Sep 21, 2018·Frontiers in Cell and Developmental Biology·Valentina BožokUrmas Arumäe
Jul 4, 2018·Signal Transduction and Targeted Therapy·Qi ChenCaiyun Fu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis