PMID: 9159165May 27, 1997Paper

Fas ligand deficiency in HIV disease

Proceedings of the National Academy of Sciences of the United States of America
S SiegD Kaplan

Abstract

Apoptosis is postulated to be involved as an anti-viral immune mechanism by killing infected cells before viral replication has occurred. The Fas-Fas ligand interaction is a powerful regulator of T cell apoptosis and could potentially act as a potent anti-viral immune mechanism against T cell tropic virus such as human immunodeficiency virus (HIV). We investigated the status of Fas ligand in peripheral blood mononuclear cells (PBMCs) obtained from persons infected with HIV. We found that monocytes in freshly isolated PBMCs from healthy individuals possess cell surface Fas ligand. In contrast, monocytes in freshly isolated PBMCs from HIV-infected patients had no detectable Fas ligand on the cell surface. Consistent with these findings of surface expression, Fas ligand activity was deficient in the cells from HIV-infected persons. The effect of replacing Fas ligand activity on HIV production by patients' cells was assessed in an in vitro assay. The addition of a functional anti-Fas antibody to PBMCs from HIV-infected individuals inhibited viral production by greater than 90% without affecting lymphocytic function. These findings suggest the possibility of a new therapeutic modality for the treatment of HIV-infected individuals ba...Continue Reading

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Citations

Dec 18, 2001·International Journal of Cancer. Journal International Du Cancer·R YangA Gruber
Jan 8, 1999·International Journal of Clinical & Laboratory Research·F SilvestrisF Dammacco
Dec 3, 1999·European Journal of Clinical Investigation·F SilvestrisF Dammacco
Apr 2, 1999·Immunology and Cell Biology·A Jaworowski, S M Crowe
Nov 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·E GaraciR Levi-Montalcini
Oct 11, 2005·FEBS Letters·Heike BantelKlaus Schulze-Osthoff
Apr 23, 2003·Journal of the European Academy of Dermatology and Venereology : JEADV·D J Bell, D H Dockrell
Mar 17, 1999·Clinical Immunology : the Official Journal of the Clinical Immunology Society·D E LewisC Kozinetz
Nov 18, 2003·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·D H Dockrell
Mar 15, 2005·Reviews in Medical Virology·Yoshiharu Miura, Yoshio Koyanagi
Mar 14, 2000·Cell Death and Differentiation·J R Baker, J D Bretz
Apr 28, 2000·International Immunology·L Mincheva-NilssonV Baranov
Feb 15, 2000·International Reviews of Immunology·S Hahn, P Erb
Sep 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·J WangM A Norcross
Jan 22, 2002·Archives of Pathology & Laboratory Medicine·Liqiang Wang, Patrick A Adegboyega

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