PMID: 9448311Mar 14, 1998Paper

Fas ligand gene transfer to the vessel wall inhibits neointima formation and overrides the adenovirus-mediated T cell response

Proceedings of the National Academy of Sciences of the United States of America
M SataK Walsh

Abstract

Proliferation of vascular smooth muscle cells (VSMCs) in response to injury plays a key role in the pathogenesis of vascular disorders. Fas ligand (FasL) induces apoptosis in Fas-bearing cells, and its expression on activated T cells contributes to the regulation of the immune response and physiological cell turnover. Here, we show that a replication-defective adenovirus encoding FasL (Ad-FasL) induced apoptosis in Fas-bearing VSMCs. When introduced locally to balloon-injured rat carotid arteries, a well characterized model of a VSMC-derived lesion, Ad-FasL functioned as a potent inhibitor of neointima formation. In rats immunized with an empty adenoviral vector, robust T cell infiltration of the vessel wall was detected after local delivery of a beta-galactosidase-expressing virus (Ad-betagal), whereas T cell infiltrates were not detected after local delivery of Ad-FasL. Prior immunization prevented beta-galactosidase expression from Ad-betagal, whereas the expression of the FasL transgene was unaffected. When Ad-betagal and Ad-FasL were delivered together to preimmunized animals, T cell infiltration was reduced and beta-galactosidase expression was restored. These data demonstrate that Fas ligand gene transfer can effectively...Continue Reading

References

Oct 1, 1992·The Journal of Clinical Investigation·S NikolL Weir
Nov 11, 1992·Journal of the American College of Cardiology·R S SchwartzE J Topol
Sep 1, 1991·The Journal of Clinical Investigation·M W MajeskyM A Reidy
Feb 1, 1991·Journal of the American College of Cardiology·M NobuyoshiK Kim
Nov 17, 1995·Science·T S GriffithT A Ferguson
Mar 10, 1995·Science·S Nagata, P Golstein
Oct 19, 1995·Nature·D BellgrauR C Duke
Sep 1, 1995·Journal of the American College of Cardiology·G R DussaillantM B Leon
Aug 26, 1993·Nature·J OgasawaraS Nagata
Oct 25, 1994·Proceedings of the National Academy of Sciences of the United States of America·R J GuzmanT Finkel
Sep 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·R MorishitaV J Dzau
May 10, 1994·Proceedings of the National Academy of Sciences of the United States of America·Y YangJ M Wilson
Feb 22, 1996·Nature·H YagitaK Okumura
Feb 1, 1997·Nature Medicine·K SeinoH Yagita
Mar 15, 1997·The Journal of Clinical Investigation·P SaasP Y Dietrich

❮ Previous
Next ❯

Citations

Feb 24, 2000·The Journal of Pathology·M M Kockx, M W Knaapen
Nov 12, 2009·Apoptosis : an International Journal on Programmed Cell Death·Lei LvJiwei Zhang
Jul 27, 2001·Molecular Aspects of Medicine·G M Rubanyi
Feb 16, 2000·Lancet·S Ylä-Herttuala, J F Martin
Jun 19, 2001·Experimental Gerontology·M Mayr, Q Xu
Oct 31, 1998·Current Opinion in Immunology·D M BriscoeA H Lichtman
Jan 1, 2003·Transplant Immunology·Sandrine CappellessoYvon Lebranchu
Oct 7, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Gang ChengLijun Zhu
Apr 6, 1999·Trends in Cardiovascular Medicine·K Walsh, M Sata
Sep 6, 2003·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Murray H KownRobert C Robbins
Apr 14, 1999·Molecular Medicine Today·K Walsh, M Sata
Sep 1, 2001·Environmental Toxicology and Pharmacology·C K Sen, S Roy
Aug 21, 2003·Trends in Molecular Medicine·Filomena de NigrisClaudio Napoli
Jul 6, 2000·British Journal of Pharmacology·Z Mallat, A Tedgui
Oct 27, 2001·Acta Physiologica Scandinavica·R C Smith, K Walsh
Apr 21, 2004·The Journal of Experimental Medicine·Tamar AprahamianKenneth Walsh
Jan 26, 2000·Human Gene Therapy·J T BruderI Kovesdi
Feb 28, 2002·Human Gene Therapy·Bruce D KlugherzRobert J Levy
Nov 5, 1998·The Journal of Clinical Investigation·M Sata, K Walsh
May 3, 2000·The Journal of Clinical Investigation·D P NelsonJ Robbins
Oct 3, 2002·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Masataka SataRyozo Nagai
Sep 12, 2000·Current Cardiology Reports·R C Smith, K Walsh
Mar 8, 2003·International Journal of Cardiovascular Interventions·Noel M CapliceDavid R Holmes
Nov 12, 2002·International Reviews of Immunology·Thomas A FergusonThomas S Griffith
Jun 29, 2013·Chinese Medical Sciences Journal = Chung-kuo I Hsüeh K'o Hsüeh Tsa Chih·Li LiDe-pei Liu
Jan 12, 2010·International Journal of Cardiology·Bin LiuJin-Kun Wen
Jan 24, 2015·Journal of the Science of Food and Agriculture·Kuei-Chuan ChanChau-Jong Wang
Nov 13, 2004·Stem Cells·Osnat Bohana-Kashtan, Curt I Civin
Mar 8, 2005·Journal of Thrombosis and Haemostasis : JTH·M M KavurmaL M Khachigian
Oct 6, 2005·Journal of Cellular and Molecular Medicine·Masataka SataIbuki Shirakawa
Aug 2, 2005·Seminars in Cancer Biology·Burkhard BrandtThomas Dittmar
Jan 15, 2002·Cardiology Clinics·Y Chandrashekhar, S Sen
Aug 23, 2001·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·N V GuevaraL Chan
Jul 27, 1999·Current Opinion in Chemical Biology·T L YueR R Ruffolo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis