Fas-positive lymphocytes are associated with systemic inflammation in obstructive sleep apnea syndrome

Sleep & Breathing = Schlaf & Atmung
J Domagała-KulawikTomasz Skirecki

Abstract

Obstructive sleep apnea syndrome (OSAS) is associated with alterations in immune system which may lead to serious complications. The aim of this study was to explore lymphocyte populations in OSAS with special attention to the Fas-positive cells. Fifty-one patients with confirmed OSA and 20 healthy subjects were investigated. The OSA severity indices, data concerning comorbidities, and markers of inflammation and metabolic disorders were collected. Flow cytometry was used to analyze the lymphocyte profile and expression of Fas receptors (CD95). Concentration of adiponectin, IL-1β, TNF-α, and sFas were measured. Proportions of Fas-positive cells in the pool of CD4+ and Fas-positive in the pool of CD8+ cells in the blood of patients were significantly increased when compared with healthy subjects (74.5% vs. 65.6% and 78.8% vs.70.9%, respectively, p < 0.05). No correlation with OSA severity was found. However, the proportion and number of Fas+ cells were elevated in obese patients, in non-smokers, and in patients suffering from COPD and hypertension. There were several significant relations of Fas+ cells with inflammatory markers of systemic inflammation. Lymphocytes with the expression of Fas receptor are associated with systemic...Continue Reading

References

May 20, 2003·Immunological Reviews·Andreas KruegerPeter H Krammer
May 3, 2005·The European Respiratory Journal·L DyugovskayaL Lavie
Nov 23, 2006·Respiratory Medicine·Joanna Domagała-KulawikRyszarda Chazan
Nov 17, 2007·American Journal of Respiratory and Critical Care Medicine·Larissa DyugovskayaLena Lavie
Jun 21, 2011·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Andrew E HoganDonal O'Shea
Jul 9, 2014·Journal of Thrombosis and Thrombolysis·Handan Inonu KoseogluOsman Demir
Jun 24, 2015·Mediators of Inflammation·Joanna Domagała-KulawikTomasz Skirecki
Jul 24, 2015·Sleep & Breathing = Schlaf & Atmung·Francisco Fábio Ferreira de LimaLia Bittencourt
Feb 3, 2016·Chest·Cynthia W BaffiFernando Holguin
Apr 21, 2017·Frontiers in Immunology·Akiko YamadaNaozumi Ishimaru
May 5, 2017·British Journal of Pharmacology·Tin KyawAlex Bobik
Oct 13, 2017·Frontiers in Immunology·Matthieu Le GalloPatrick Legembre
Oct 17, 2017·The FEBS Journal·Jean-Philippe Guégan, Patrick Legembre

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Citations

Apr 8, 2020·International Journal of Chronic Obstructive Pulmonary Disease·Xia YangJie Cao
Dec 4, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christina PolaskyRalph Pries

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Methods Mentioned

BETA
blood collection
FACS
ELISA
flow cytometry

Software Mentioned

Diva
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