Fas signaling is involved in the control of hair follicle response to chemotherapy

Cancer Research
Andrei A SharovVladimir A Botchkarev

Abstract

Chemotherapeutic agents induce p53-dependent apoptosis in the hair follicle (HF) resulting in hair loss, a common side effect of cancer therapy. Here, we show that Fas as a p53 target plays important role in the HF response to cyclophosphamide. Specifically, we demonstrate that Fas is up-regulated in HF keratinocytes after cyclophosphamide treatment, Fas ligand-neutralizing antibody partially inhibits HF response to cyclophosphamide in wild-type mice, and Fas knockout mice show significant retardation of cyclophosphamide-induced HF involution associated with reduced Fas-associated death domain and caspase-8 expression. These data raise a possibility to explore blockade of Fas signaling as a part of complex local therapy for inhibiting keratinocyte apoptosis and hair loss induced by chemotherapy.

References

Aug 12, 1999·The New England Journal of Medicine·R Paus, G Cotsarelis
Nov 13, 1999·Nature Cell Biology·V A BotchkarevR Paus
Oct 12, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·V A BotchkarevR Paus
Jul 10, 2001·The Journal of Investigative Dermatology·S Müller-RöverR Paus
Jan 22, 2003·The Journal of Investigative Dermatology·Andrei A SharovVladimir A Botchkarev
Feb 4, 2003·Nature Reviews. Cancer·Andrei V Gudkov, Elena A Komarova
Mar 26, 2003·Cell Death and Differentiation·M E Peter, P H Krammer
Apr 2, 2003·Molecular Cell·James J Manfredi
Jun 14, 2003·The EMBO Journal·Andrei A SharovVladimir A Botchkarev
Aug 5, 2003·The Journal of Investigative Dermatology. Symposium Proceedings·Vladimir A Botchkarev
Sep 23, 2003·Cellular Signalling·James F Curtin, Thomas G Cotter
Dec 10, 2003·Oncogene·Jordan S Fridman, Scott W Lowe

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Citations

Jul 30, 2009·Cell and Tissue Research·Masashi ShinKunio Fujiwara
Jul 31, 2013·PloS One·Kyle J BichselLaura A Hansen
Feb 24, 2016·The Journal of Investigative Dermatology·Vladimir A Botchkarev, Andrey A Sharov
Feb 2, 2013·The Lancet Oncology·Ralf PausVladimir A Botchkarev
Dec 20, 2011·Journal of the American Academy of Dermatology·Susan Y ChonRashid M Rashid
Dec 16, 2005·The Journal of Investigative Dermatology·Andreya SharovVladimir A Botchkarev
Feb 3, 2007·The Journal of Investigative Dermatology·Frank SiebenhaarVladimir A Botchkarev
Feb 14, 2006·The Journal of Investigative Dermatology·Silvia SelleriCristiano Rumio
Jul 8, 2014·The Journal of Investigative Dermatology·Tatyana Y SharovaAndrey A Sharov
Jan 1, 2008·Life Sciences·Naomi Nakashima-KamimuraShigeo Ohta
Dec 7, 2006·The American Journal of Pathology·Michael Y FessingVladimir A Botchkarev
Sep 13, 2019·EMBO Molecular Medicine·Talveen S PurbaRalf Paus
Jul 20, 2020·The Journal of Investigative Dermatology·Iain S HaslamZhiCao Yue

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