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Fas signaling-mediated TH 9 cell differentiation favors bowel inflammation and antitumor functions

Nature Communications

Jul 2, 2019

Ying-Ying ShenJian-Li Wang

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Abstract

Fas induces apoptosis in activated T cell to maintain immune homeostasis, but the effects of non-apoptotic Fas signaling on T cells remain unclear. Here we show that Fas promotes TH9 cell differentiation by activating NF-κB via Ca2+-dependent PKC-β activation. In addition, PKC-β also ph...read more

Mentioned in this Paper

Cell Differentiation Process
Inflammatory Bowel Diseases
Ligation
Neoplasms
Phosphorylation
Protein Kinase C
T-Lymphocyte
CD4 Positive T Lymphocytes
Thyroid Hormones
Transcription, Genetic
2
1
6
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Fas signaling-mediated TH 9 cell differentiation favors bowel inflammation and antitumor functions

Nature Communications

Jul 2, 2019

Ying-Ying ShenJian-Li Wang

PMID: 31266950

DOI: 10.1038/s41467-019-10889-4

Abstract

Fas induces apoptosis in activated T cell to maintain immune homeostasis, but the effects of non-apoptotic Fas signaling on T cells remain unclear. Here we show that Fas promotes TH9 cell differentiation by activating NF-κB via Ca2+-dependent PKC-β activation. In addition, PKC-β also ph...read more

Mentioned in this Paper

Cell Differentiation Process
Inflammatory Bowel Diseases
Ligation
Neoplasms
Phosphorylation
2
1
6

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