PMID: 2509076Oct 20, 1989Paper

Fasciclin III: a novel homophilic adhesion molecule in Drosophila

Cell
P M SnowC S Goodman

Abstract

Drosophila fasciclin III is an integral membrane glycoprotein that is expressed on a subset of neurons and fasciculating axons in the developing CNS, as well as in several other tissues during development. Here we report on the isolation of a full-length cDNA encoding an 80 kd form of fasciclin III. We have used this cDNA, under heat shock control, to transfect the relatively nonadhesive Drosophila S2 cell line. Examination of these transfected cells indicates that fasciclin III is capable of mediating adhesion in a homophilic, Ca2+-independent manner. Sequence analysis reveals that fasciclin III encodes a transmembrane protein with no significant homology to any known protein, including the previously characterized families of vertebrate cell adhesion molecules. The distribution of this adhesion molecule on subsets of fasciculating axons and growth cones during Drosophila development suggests that fasciclin III plays a role in growth cone guidance.

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Mar 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·M WiglerL Chasin
Jan 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M ArquintR Dunn
Jan 1, 1989·Molecular & General Genetics : MGG·R S JokerstA L Greenleaf
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·P M SnowC S Goodman
Jan 1, 1987·Annual Review of Biochemistry·A M EdelmanE G Krebs
Mar 22, 1985·Science·D J Lipman, W R Pearson
Jan 1, 1988·Annual Review of Immunology·A F Williams, A N Barclay
Jul 5, 1985·Journal of Molecular Biology·G von Heijne
Jan 15, 1974·Biochemistry·P Y Chou, G D Fasman
Jul 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·D DiMaioT Maniatis
Mar 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·M J Bastiani, C S Goodman
Sep 21, 1984·Science·C S GoodmanJ B Thomas
Jan 1, 1983·Cold Spring Harbor Symposia on Quantitative Biology·J A RaperC S Goodman
Jun 1, 1983·European Journal of Biochemistry·G von Heijne

❮ Previous
Next ❯

Citations

Apr 11, 2000·Microscopy Research and Technique·D Rose, A Chiba
Jun 22, 2000·Journal of Neuroscience Research·Y GaoM T Filbin
Mar 1, 1991·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·S M Strittmatter, M C Fishman
Mar 1, 1992·The Journal of Experimental Zoology·A L Harrelson
Jun 1, 1993·Journal of Neurobiology·H KeshishianM E Halpern
Mar 1, 1995·Protein Science : a Publication of the Protein Society·L A CastonguayJ S Fetrow
Jul 1, 1993·Trends in Neurosciences·H Keshishian, A Chiba
Aug 1, 1994·Trends in Genetics : TIG·E Knust
Aug 1, 1991·Trends in Biochemical Sciences·M Hortsch, A J Bieber
Oct 24, 2003·Trends in Cell Biology·Michael Hortsch, Ben Margolis
Aug 5, 2000·Brain Research. Molecular Brain Research·K L AgarwalaK Yamakawa
Apr 4, 1998·Genetic Analysis : Biomolecular Engineering·B RautenstraussT Liehr
Dec 3, 1998·Genetic Analysis : Biomolecular Engineering·A B EkiciB Rautenstrauss
Apr 1, 1993·Bio/technology·J S Fetrow, S H Bryant
Jun 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·O PourquiéN M Le Douarin
Aug 30, 2012·The Journal of Biological Chemistry·Martin H J JaspersReinhard Schuh
Dec 1, 1990·The Journal of Cell Biology·F Keller, S Schacher
Aug 19, 2008·Tissue Engineering. Part a·Celeste A Berg
May 4, 2007·Neural Development·Natalia Sánchez-SorianoAndreas Prokop
Aug 16, 2013·Development·Richard E WellsMartin P Zeidler
Mar 13, 2009·PLoS Biology·Edward Málaga-TrilloClaudia A O Stuermer
Apr 25, 2000·In Vitro Cellular & Developmental Biology. Animal·A S MillerM J Milner
Oct 22, 2005·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Judith LitvinRoger Markwald
Oct 1, 1992·Experimental Cell Research·A S YapS W Manley
Jun 1, 1997·Neuron·S Raghavan, R A White
Feb 24, 2015·Journal of Experimental Botany·Zengyu LiuClara Sánchez-Rodríguez
Jul 17, 2015·The Journal of Comparative Neurology·Tzu-Yang LinChi-Hon Lee
Mar 4, 2000·Journal of Molecular Biology·S A Teichmann, C Chothia

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Adhesion Molecules in the Brain

Cell adhesion molecules found on cell surface help cells bind with other cells or the extracellular matrix to maintain structure and function. Here is the latest research on their role in the brain.

Cell eTOC

Cell is a scientific journal publishing research across a broad range of disciplines within the life sciences field. Discover the latest research from Cell here.

Axon Guidance

Axon guidance is a complex neural developmental field that investigates mechanisms through which neurons send out axons to reach its target. Here is the latest research in this domain.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.