Fasciculation and elongation zeta proteins 1 and 2: From structural flexibility to functional diversity

World Journal of Biological Chemistry
Mariana Bertini TeixeiraJörg Kobarg

Abstract

Fasciculation and elongation zeta/zygin (FEZ) proteins are a family of hub proteins and share many characteristics like high connectivity in interaction networks, they are involved in several cellular processes, evolve slowly and in general have intrinsically disordered regions. In 1985, unc-76 gene was firstly described and involved in axonal growth in C. elegans, and in 1997 Bloom and Horvitz enrolled also the human homologues genes, FEZ1 and FEZ2, in this process. While nematodes possess one gene (unc-76), mammalians have one more copy (FEZ1 and FEZ2). Several animal models have been used to study FEZ family functions like: C. elegans, D. melanogaster, R. novergicus and human cells. Complementation assays were performed and demonstrated the function conservation between paralogues. Human FEZ1 protein is more studied followed by UNC-76 and FEZ2 proteins, respectively. While FEZ1 and UNC-76 shared interaction partners, FEZ2 evolved and increased the number of protein-protein interactions (PPI) with cytoplasmatic partners. FEZ proteins are implicated in intracellular transport, acting as bivalent cargo transport adaptors in kinesin-mediated movement. Especially in light of this cellular function, this family of proteins has bee...Continue Reading

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Citations

Jan 23, 2020·Viruses·Lenka HorníkováJitka Forstová
Apr 3, 2021·Nature Communications·Robert A TumasianLuigi Ferrucci
Apr 13, 2021·Journal of Molecular Biology·Martina WirthSharon A Tooze

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Methods Mentioned

BETA
gene
circular dichroism
X-ray
two-hybrid
immunoprecipitation
FRET
transgenic
co-immunoprecipitation
genotyping
co-IP

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