Fasciculation frequency at the biceps brachii and brachialis muscles is associated with amyotrophic lateral sclerosis disease burden and activity.

Muscle & Nerve
Reuven AvidanAlon Abraham

Abstract

Fasciculations are most commonly seen in the biceps brachii muscle in amyotrophic lateral sclerosis (ALS). In this study we have explored the association between fasciculation frequency in a single location-biceps brachii and brachialis muscles (BB), and disease burden and activity. Sonographic muscle studies were performed in 90 ALS patients, 47 of whom were seen in subsequent follow-up. The association between fasciculations frequency at the BB and ALS Functional Rating Scale-Revised (ALSFRS-R) and manual muscle testing (MMT) scores was determined. High fasciculation frequency at the BB, where detection rate was the highest, was associated with shorter disease duration, greater muscle thickness, higher MMT scores, and faster rate of decline in ALSFRS-R initially, and MMT subsequently. High fasciculation frequency at the BB as determined by sonography, is associated with less impairment at time of examination, and a more active disease with a more rapid progression.

References

Jul 24, 2001·Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders : Official Publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases·B R BrooksUNKNOWN World Federation of Neurology Research Group on Motor Neuron Diseases
Jan 1, 2008·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Mamede de CarvalhoMichael Swash
Nov 6, 2008·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Mamede De Carvalho, Michael Swash
Apr 16, 2010·Journal of Neurology, Neurosurgery, and Psychiatry·Ilse M P ArtsMachiel J Zwarts
Jun 5, 2010·Journal of Neurology, Neurosurgery, and Psychiatry·C P DouglassC J McDermott
Jun 10, 2010·Journal of Neurology·Paul H GordonVincent Meininger
Jul 28, 2010·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Christian Krarup
Aug 16, 2012·Archives of Neurology·João CostaMamede de Carvalho
Apr 5, 2016·The Journal of Medical Investigation : JMI·Naoko TakamatsuRyuji Kaji
Apr 14, 2016·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Mamede de Carvalho, Michael Swash
Jan 4, 2017·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Christoph NeuwirthMarkus Weber
Mar 28, 2017·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Yukiko TsujiToshiki Mizuno
May 12, 2017·Journal of Neurology, Neurosurgery, and Psychiatry·Mamede de CarvalhoMichael Swash
Aug 17, 2018·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Jun TsugawaMatthew C Kiernan
Oct 8, 2018·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·J F Vázquez-CostaT Sevilla
Apr 17, 2019·Muscle & Nerve·Lisa D Hobson-Webb, Zachary Simmons
May 11, 2020·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Alon AbrahamVivian E Drory
Jun 7, 2020·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Alon AbrahamVera Bril

❮ Previous
Next ❯

Citations

Jul 28, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Tsun-Haw TohNortina Shahrizaila

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amyloid Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS) is a progressive nervous system disease associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.

Related Papers

Journal of Neurology, Neurosurgery, and Psychiatry
Mamede de CarvalhoMichael Swash
Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
Yukiko TsujiToshiki Mizuno
Journal of Neurology, Neurosurgery, and Psychiatry
Mamede de CarvalhoMichael Swash
© 2021 Meta ULC. All rights reserved