Abstract
Immature teratoma of the human ovary is a rare disease, and its diagnosis and grading are currently based on histologic evaluation of the presence and amount of immature neural components in the tumor. Despite the importance of tumor grading, immature neural components especially without rosette formation are difficult to identify, partly because useful biomarkers for them are not yet available. Toward this goal, we investigated 16 immature teratomas from human ovaries as well as 10 of those derived from murine embryonic stem cells transplanted into immunodeficient mice. Immunohistochemistry was performed for cytokeratin, glial fibrillary acidic protein, S100, and fascin. It was demonstrated that glial fibrillary acidic protein and S100 expression was not observed in the immature neural components of immature teratomas derived from both human ovary and embryonic stem cells, although their expression was detected in mature neural tissues. In contrast, fascin immunopositivity was clearly found in both mature and immature neural components regardless of rosette formation in immature teratomas derived from both human ovary and embryonic stem cells. Assessment of immature neural components by fascin immunostaining yielded the same o...Continue Reading
References
May 1, 1976·Cancer·H J NorrisW L Benson
Jun 1, 1990·Pathology, Research and Practice·P LahdenneM Miettinen
May 1, 1990·Acta Pathologica Japonica·K NotoharaM Awai
Jan 1, 1989·Acta Neuropathologica·T Sangruchi, R A Sobel
Jun 15, 1983·American Journal of Obstetrics and Gynecology·H GallionD F Powell
May 1, 1984·Experimental Cell Research·A M WobusJ Schöneich
Oct 1, 1994·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·D M O'Connor, H J Norris
Jul 1, 1960·Cancer·W M THURLBECK, R E SCULLY
May 2, 2006·Obstetrics and Gynecology·Harriet O SmithClifford R Qualls
Sep 23, 2006·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Lawrence M Roth, Aleksander Talerman
Nov 24, 2006·The American Journal of Surgical Pathology·Debra L ZyngerXiming J Yang
Apr 28, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Ji Hoon PhiKyu-Chang Wang
Nov 13, 2007·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Kah-Wai NganYi-Yueh Hsieh
Nov 14, 2007·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Fa-Ren ZhangEn-Min Li
Apr 28, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Anuradha GopalanSatish K Tickoo
Jan 26, 2010·Human Pathology·Liang ChengLawrence M Roth
Aug 18, 2010·Communicative & Integrative Biology·Laura M Machesky, Ang Li
Jan 7, 2011·World Journal of Pediatrics : WJP·Song GuMin-Zhi Yin
Mar 11, 2011·Nature Reviews. Cancer·Uri Ben-David, Nissim Benvenisty
Aug 1, 2012·Oncology Letters·Junichiro SatoAtsushi Kurata
Oct 16, 2016·Journal of Pathology and Translational Medicine·Yun ChaiKyu-Rae Kim
Nov 29, 2016·Experimental Animals·Katsuyoshi KumagaiKatsuko Sudo
Dec 22, 2016·The International Journal of Developmental Biology·Ivan Damjanov, Peter W Andrews
Mar 21, 2017·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Masako Hongo-KohamaMasahiko Kuroda
May 13, 2017·Stem Cell Reports·Marga J BoumaChristian Freund