Fascin is a potential biomarker for early-stage oesophageal squamous cell carcinoma

Journal of Clinical Pathology
H ZhangE M Li

Abstract

Fascin, an actin-binding protein, is usually expressed at a low level in normal epithelium, but is markedly up regulated in several types of carcinomas. Reports on fascin expression in oesophageal squamous cell carcinoma (ESCC) and precancerous lesions remain rare. To show the roles of fascin in the progression from normal epithelium to invasive ESCC. Fascin expression in 102 sections embedded in paraffin wax, including samples of normal mucosa (n = 20), dysplasia (n = 10), ESCC (n = 62) and special sections (n = 10) of a full-length mucosa layer from the distant margin to the cancer focus of the excised oesophagus, and 49 fresh specimens of ESCC was analysed by immunohistochemistry, western blot and real-time reverse transcription-polymerase chain reaction. Fascin expression in ESCC cell lines was also investigated. In the immunohistochemical study, the positive rate of fascin was significantly higher in the tumour tissue than in the normal epithelium (p = 0.020), but no significant difference was shown between ESCC and dysplasia (p = 1.000). Immunostaining for fascin was only apparent in the basal layer of the normal epithelium. However, in the dysplasia, positive staining was observed in most of the heterogeneous cells from ...Continue Reading

References

Oct 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·J BryanJ Wulfkuhle
Apr 15, 1996·Cancer·K KitamuraK Sugimachi
Feb 24, 2001·Current Problems in Cancer·R Wong, R Malthaner
Jul 26, 2002·Journal of Cutaneous Pathology·Viktor N GoncharukJ Andrew Carlson
Jan 1, 2003·The American Journal of Pathology·Aida U JawhariJosephine C Adams
Dec 6, 2003·The New England Journal of Medicine·Peter C Enzinger, Robert J Mayer
Jun 29, 2004·International Journal of Cancer. Journal International Du Cancer·Martha C KimosStephen J Meltzer
Sep 29, 2004·Trends in Cardiovascular Medicine·Josephine C Adams
Nov 24, 2004·Oncology·Yosuke HashimotoMasayuki Imamura
Apr 9, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yosuke HashimotoYutaka Shimada
Sep 28, 2005·Biochemical and Biophysical Research Communications·J J XieE M Li

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Citations

Mar 18, 2008·Journal of Cancer Research and Clinical Oncology·Guang ChenEn-Min Li
Nov 20, 2009·The Journal of Laryngology and Otology·A DurmazS Yalcin
Sep 18, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D WuL Liu
Sep 11, 2009·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Jian ZouShixi Liu
Apr 23, 2010·The American Journal of Surgical Pathology·Charles ChanStephen Clarke
Feb 27, 2008·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Armagan GunalMurat Beyzadeoglu
Jan 28, 2012·Acta Histochemica Et Cytochemica·Yumiko ShimamuraMasashi Sugasawa
Aug 18, 2010·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Qing ZhaoLi-Yan Xu
Nov 14, 2007·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Fa-Ren ZhangEn-Min Li
Feb 20, 2008·Neoplasia : an International Journal for Oncology Research·Jeong Hyun HwangJames T Rutka
Jan 24, 2009·International Journal of Cancer. Journal International Du Cancer·Jian-Jun XieEn-Min Li
Jan 26, 2010·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Wei-Sen WangEn-Min Li
Oct 11, 2014·International Journal of Cancer. Journal International Du Cancer·Yafeng Ma, Laura M Machesky
Aug 22, 2009·Journal of Surgical Oncology·Tomohiro IguchiMasazumi Tsuneyoshi
Jan 28, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Bing-Li WuEn-Min Li
Jul 12, 2011·Cancer Biology & Therapy·Harsh PawarAkhilesh Pandey
Oct 7, 2011·Cell Adhesion & Migration·Antti ArjonenJohanna Ivaska
Sep 2, 2009·Laboratory Investigation; a Journal of Technical Methods and Pathology·Manabu OnoderaYasuni Nakanuma
Oct 19, 2011·Laboratory Investigation; a Journal of Technical Methods and Pathology·Naoki UyamaJiro Fujimoto
Jan 22, 2009·Electrophoresis·Mariella Gruber-OlipitzGert Lubec
Apr 4, 2020·European Journal of Gastroenterology & Hepatology·Abhilash PerisettiHemant Goyal
Aug 1, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Ze-Peng DuLi-Yan Xu
Feb 23, 2021·Molecular Therapy Oncolytics·Hongliang LiuWei Gao
Mar 7, 2021·Cancers·Hugo de JongeClaudia Scotti
May 22, 2021·Journal of Cellular Physiology·Lin-Lin HuShao-Chen Sun

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