Fasciola hepatica: disruption of spermatogenesis by the fasciolicide compound alpha.

Parasitology Research
Maeve McConvilleIan Fairweather

Abstract

Sheep infected with the triclabendazole-susceptible Cullompton isolate of Fasciola hepatica were dosed with 15 mg/kg of compound alpha at 12 weeks post-infection. Adult flukes were recovered from the bile ducts at 24, 48, and 72 h post-treatment (p.t.). Changes to the spermatogenic cells in the testis were examined by histology and transmission electron microscopy. Disruption to the testes became increasingly severe over time. The testis tubules shrank in size, became vacuolated, and contained fewer cells. Identification of cell types became difficult, and apoptotic eosinophilic bodies were the predominant feature at 72 h p.t. Changes to the spermatogonia were evident at 24 h p.t., the cells containing swollen and electron-lucent mitochondria. The proportion of tertiary spermatogonia increased at 48 h p.t., and they showed signs of autophagy. Multinucleate spermatogonia were a feature of drug treatment at this time point, and they contained autophagic vacuoles. By 72 h p.t., it was difficult to identify primary and secondary spermatogonia, and there were no recognisable clusters of tertiary spermatogonia. Most spermatogonial cells were multinucleate and in the process of breaking down. With regard to the primary spermatocytes, ...Continue Reading

References

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Sep 18, 1999·The Veterinary Journal·I Fairweather, J C Boray
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Nov 26, 2008·Veterinary Parasitology·L HalfertyI Fairweather
Apr 16, 2009·Journal of Helminthology·I Fairweather
Apr 21, 2009·Veterinary Parasitology·Santiago Mas-ComaMaria Dolores Bargues

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Citations

Jan 10, 2012·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·R ToledoB Fried
Jan 14, 2011·Veterinary Parasitology·I Fairweather
Feb 15, 2014·Acta Crystallographica. Section E, Structure Reports Online·Miguel Flores-RamosMarcos Flores-Alamo
Feb 21, 2019·Revista brasileira de parasitologia veterinária = Brazilian journal of veterinary parasitology : Órgão Oficial do Colégio Brasileiro de Parasitologia Veterinária·Milena Batista CarneiroFabio Barbour Scott

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