Fasciola hepatica: effects on the antioxidative properties and lipid peroxidation of rat serum

Experimental Parasitology
L KolodziejczykE Skrzydlewska

Abstract

Fasciola hepatica infection is accompanied by increased formation of reactive oxygen species. The aim of this study was to analyze antioxidative properties of rat serum in the course of fasciolosis. Wistar rats were infected per os with 30 metacercariae of F. hepatica. Activities of antioxidant enzymes and concentrations of non-enzymatic antioxidants in serum were determined at 4, 7, and 10 weeks post-infection (wpi). Activity of superoxide dismutase (Cu, Zn-SOD) significantly decreased (by 35% during the migratory phase, by 40 and 23% at 7 and 10 wpi, respectively), while glutathione reductase activity significantly increased (by 62, 65, and 41%, at 4, 7, and 10 wpi, respectively). No significant changes were found in the activity of glutathione peroxidase. Significant decreases in concentrations of reduced glutathione, vitamins C, E, and A were observed, particularly during the migratory phase of fasciolosis (at 4 wpi). These changes were accompanied by enhancement of lipid peroxidation processes as evidenced by increased levels of malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE). Concentrations of MDA and 4-HNE at 4 wpi increased by 38% and by 59%. MDA increased by 51% at 7 wpi and by 79% at 10 wpi, while 4-HNE increased b...Continue Reading

References

Jan 15, 1977·The Veterinary Record·P H AndersonD S Patterson
May 1, 1992·International Journal for Parasitology·N C SmithJ C Boray
Jan 1, 1991·Free Radical Biology & Medicine·H EsterbauerH Zollner
Sep 1, 1989·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·R Maffei FacinoI Casciarri
Jan 1, 1985·Journal of Free Radicals in Biology & Medicine·S D AustC E Thomas
Jan 1, 1987·Critical Reviews in Toxicology·A A Horton, S Fairhurst
Apr 1, 1971·Journal of Comparative Pathology·J D Dargie, W Mulligan
Feb 1, 1993·The Biochemical Journal·S Gebicki, J M Gebicki
Jan 30, 1999·Journal of Pharmaceutical and Biomedical Analysis·D IvanovićM Medenica
May 27, 1999·Parasitology Research·S Sánchez-CamposJ González-Gallego
Apr 24, 2001·Journal of Helminthology·G Sadeghi-Hashjin, S Naem
Jul 11, 2002·Parasitology Research·Elzbieta Wandurska-Nowak, Justyna Wiśniewska
Dec 21, 2004·Redox Report : Communications in Free Radical Research·Paul PflugerRegina Brigelius-Flohé
Jun 2, 2005·Parasitology Research·L KolodziejczykE Skrzydlewska

Citations

Jul 19, 2011·Parasitology Research·Agnieszka WesołowskaH Wedrychowicz
Aug 15, 2007·Pakistan Journal of Biological Sciences : PJBS·Azra A ShaikhF M Bilqees
Mar 19, 2014·Veterinary Parasitology·Somayeh BahramiAhmad Oryan
Jun 24, 2014·Research in Veterinary Science·J M Martínez-PérezM Martínez-Valladares
Apr 30, 2015·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·L KolodziejczykE Skrzydlewska
Dec 22, 2015·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology·Somayeh BahramiArash Jafari
Aug 28, 2015·Experimental Parasitology·Nathieli B BottariAleksandro S Da Silva
Feb 19, 2013·Veterinary Parasitology·M HeidarpourE Moghdass

Related Concepts

4-hydroxy-2-nonenal, (E)-isomer
Aldehydes
Metazoa
Antioxidant Effect
Magnorbin
Bile Duct Structure
Fasciola hepatica
Fascioliasis
Reduced Glutathione
Selenoglutathione Peroxidase

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