Fasciola hepatica: effects on the antioxidative properties and lipid peroxidation of rat serum

Experimental Parasitology
L KolodziejczykE Skrzydlewska


Fasciola hepatica infection is accompanied by increased formation of reactive oxygen species. The aim of this study was to analyze antioxidative properties of rat serum in the course of fasciolosis. Wistar rats were infected per os with 30 metacercariae of F. hepatica. Activities of antioxidant enzymes and concentrations of non-enzymatic antioxidants in serum were determined at 4, 7, and 10 weeks post-infection (wpi). Activity of superoxide dismutase (Cu, Zn-SOD) significantly decreased (by 35% during the migratory phase, by 40 and 23% at 7 and 10 wpi, respectively), while glutathione reductase activity significantly increased (by 62, 65, and 41%, at 4, 7, and 10 wpi, respectively). No significant changes were found in the activity of glutathione peroxidase. Significant decreases in concentrations of reduced glutathione, vitamins C, E, and A were observed, particularly during the migratory phase of fasciolosis (at 4 wpi). These changes were accompanied by enhancement of lipid peroxidation processes as evidenced by increased levels of malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE). Concentrations of MDA and 4-HNE at 4 wpi increased by 38% and by 59%. MDA increased by 51% at 7 wpi and by 79% at 10 wpi, while 4-HNE increased b...Continue Reading


Jan 15, 1977·The Veterinary Record·P H AndersonD S Patterson
May 1, 1992·International Journal for Parasitology·N C SmithJ C Boray
Jan 1, 1991·Free Radical Biology & Medicine·H EsterbauerH Zollner
Sep 1, 1989·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·R Maffei FacinoI Casciarri
Jan 1, 1985·Journal of Free Radicals in Biology & Medicine·S D AustC E Thomas
Jan 1, 1987·Critical Reviews in Toxicology·A A Horton, S Fairhurst
Apr 1, 1971·Journal of Comparative Pathology·J D Dargie, W Mulligan
Feb 1, 1993·The Biochemical Journal·S Gebicki, J M Gebicki
Jan 30, 1999·Journal of Pharmaceutical and Biomedical Analysis·D IvanovićM Medenica
May 27, 1999·Parasitology Research·S Sánchez-CamposJ González-Gallego
Apr 24, 2001·Journal of Helminthology·G Sadeghi-Hashjin, S Naem
Jul 11, 2002·Parasitology Research·Elzbieta Wandurska-Nowak, Justyna Wiśniewska
Dec 21, 2004·Redox Report : Communications in Free Radical Research·Paul PflugerRegina Brigelius-Flohé
Jun 2, 2005·Parasitology Research·L KolodziejczykE Skrzydlewska


Jul 19, 2011·Parasitology Research·Agnieszka WesołowskaH Wedrychowicz
Aug 15, 2007·Pakistan Journal of Biological Sciences : PJBS·Azra A ShaikhF M Bilqees
Mar 19, 2014·Veterinary Parasitology·Somayeh BahramiAhmad Oryan
Jun 24, 2014·Research in Veterinary Science·J M Martínez-PérezM Martínez-Valladares
Apr 30, 2015·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·L KolodziejczykE Skrzydlewska
Dec 22, 2015·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology·Somayeh BahramiArash Jafari
Aug 28, 2015·Experimental Parasitology·Nathieli B BottariAleksandro S Da Silva
Feb 19, 2013·Veterinary Parasitology·M HeidarpourE Moghdass

Related Concepts

4-hydroxy-2-nonenal, (E)-isomer
Antioxidant Effect
Bile Duct Structure
Fasciola hepatica
Reduced Glutathione
Selenoglutathione Peroxidase

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

The Tendon Seed Network

Tendons are rich in the extracellular matrix and are abundant throughout the body providing essential roles including structure and mobility. The transcriptome of tendons is being compiled to understand the micro-anatomical functioning of tendons. Discover the latest research pertaining to the Tendon Seed Network here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.


Incretins are metabolic hormones that stimulate a decrease in glucose levels in the blood and they have been implicated in glycemic regulation in the remission phase of type 1 diabetes. Here is the latest research.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Long COVID-19

“Long Covid-19” describes illness in patients who are reporting long-lasting effects of the SARS-CoV-19 infection, often long after they have recovered from acute Covid-19. Ongoing health issues often reported include low exercise tolerance and breathing difficulties, chronic tiredness, and mental health problems such as post-traumatic stress disorder and depression. This feed follows the latest research into Long Covid.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.