PMID: 15379423Sep 24, 2004Paper

Fast acquisition sagittal T1 magnetic resonance imaging (FAST1-MRI): a new imaging approach for the diagnosis of growth hormone deficiency

Journal of Pediatric Endocrinology & Metabolism : JPEM
Carlos A LonguiOsmar Monte

Abstract

Routine magnetic resonance imaging (MRI) is an established standard method to investigate the etiology of pituitary insufficiency. Among the anatomic abnormalities usually observed, ectopic hyperintense signal on T1 sequence is the most frequently associated with pituitary dysfunction. We developed a new protocol (FAST1-MRI) which is able to detect anatomic hypothalamic-pituitary abnormalities with 100% concordance when compared to the routine MRI protocol. FAST1-MRI takes only 3.25 minutes, and is performed without contrast, sedation or anesthesia. We studied 17 controls and 31 patients with growth hormone (GH) deficiency (18/31 with abnormal MRI). Patients with ectopic hyperintense signal were shorter in height, had lower IGF-I and IGFBP-3 levels, and reduced GH response after clonidine. In conclusion, we describe a new simplified MRI protocol that we propose should be used in the diagnosis of GH deficiency.

References

Mar 11, 2000·Journal of Pediatric Endocrinology & Metabolism : JPEM·N KandemirA Besim
Jul 25, 2000·Journal of Pediatric Endocrinology & Metabolism : JPEM·F MészárosH Frisch
Jan 12, 2001·Journal of Pediatric Endocrinology & Metabolism : JPEM·V TillmannP E Clayton
Dec 12, 2001·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·P C SizonenkoZ Laron

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Citations

Oct 1, 2010·The Neuroradiology Journal·V KyriacouI Tsitouridis

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