Fast and efficient (18) F-labeling by [(18) f]fluorophenylazocarboxylic esters

Chemistry : a European Journal
Stefanie K FehlerMarkus R Heinrich

Abstract

Introduction of [(18) F]fluoride ion into the aromatic core of phenylazocarboxylic esters was achieved in only 30 seconds, with radiochemical yields of up to 95 % (85(±10) %). For labeling purposes, the resulting (18) F-substituted azoester can be further converted in radical-arylation reactions to give biaryls, or in substitutions at its carbonyl unit to produce azocarboxamides.

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Citations

Sep 25, 2015·The Journal of Organic Chemistry·Roman Lasch, Markus R Heinrich
Sep 10, 2016·Pharmaceutical Patent Analyst·Andrew V MossinePeter Jh Scott
Sep 3, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Natascha NebelOlaf Prante
Jun 14, 2017·Chemical Society Reviews·Dion van der BornDanielle J Vugts
Aug 27, 2014·Angewandte Chemie·Stefanie K FehlerMarkus R Heinrich
Dec 29, 2015·Journal of Labelled Compounds & Radiopharmaceuticals·Natascha NebelOlaf Prante
Jan 13, 2018·The Journal of Organic Chemistry·Min Hye Kim, Jinho Kim

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