Fast and robust simultaneous determination of three veterinary antibiotics in groundwater and surface water using a tandem solid-phase extraction with high-performance liquid chromatography-UV detection

Journal of Chromatography. a
Paul A BlackwellPaul Kay

Abstract

A simple and robust analytical method is presented in which the three veterinary antibiotics oxytetracycline (OTC), sulfachloropyridazine (SCP) and tylosin (TYL) were simultaneously determined in surface water and groundwater. The three compounds were simultaneously extracted from the water samples using a mixture of methanol, EDTA and McIlvaine buffer (citric acid and sodium orthophosphate) and then cleaned-up and pre-concentrated by solid-phase extraction using sacrificial Isolute strong anion-exchange cartridges, to remove interfering organic material, and Waters Oasis hydrophilic-liphophilic balance polymer cartridges, to retain the compounds, in tandem. Analysis was performed using liquid chromatography with ultraviolet detection. Recoveries for river water samples spiked at 10 and 1 microgl(-1) were respectively 99.6+/-4.6 and 99.4+/-8.4% for OTC; 99.9+/-2.2 and 105.0+/-5.7% for SCP; and 94.9+/-2.4 and 71.6+/-8.2% for TYL. Overall limits of detection based on pre-concentrating 400 ml of sample were 0.35 microgl(-1) for OTC and TYL and 0.25 microgl(-1) for SCP.

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Citations

Feb 18, 2006·Analytical and Bioanalytical Chemistry·Anne Marie Jacobsen, Bent Halling-Sørensen
Dec 14, 2011·Environmental Science and Pollution Research International·Manuel Garcia-KäuferVolker Mersch-Sundermann
Mar 14, 2012·Analytical and Bioanalytical Chemistry·Carmen Lidia ChitescuAlida Adriana Maria Linda Stolker
May 22, 2013·Journal of Environmental and Public Health·Mohsen HeidariMohammad Mehdi Amin
Jan 6, 2007·Chemosphere·Paul A BlackwellAlistair B A Boxall
Jul 19, 2016·Environment International·Isabel T Carvalho, Lúcia Santos
Mar 21, 2018·Environmental Science and Pollution Research International·Elena OkadaJosé Luis Costa
Aug 9, 2012·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Prakash SrinivasanAlistair L Wilkins
Sep 22, 2017·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Zhi WangZhaode Mu
Jun 5, 2008·Environmental Science & Technology·Jianying HuYoichi Kamagata
Mar 17, 2005·Journal of Agricultural and Food Chemistry·Paul A BlackwellHelen Noble

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