PMID: 7155803Dec 1, 1982

Fast bicarbonate-chloride exchange between brain cells and brain extracellular fluid in respiratory acidosis

Pflügers Archiv : European journal of physiology
H R Ahmad, H H Loeschcke

Abstract

The extracellular pH, PCO2, and [Cl-] at the surface of the brain cortex, expiratory PCO2 and arterial blood pressure were continuously recorded in anaesthetized and artificially ventilated cats. The observations from such a preparation were: 1. In response to a nearly step increase in end-tidal PCO2, the brain ECF pH, PCO2, [Cl-] and calculated [HCO-3] changed in the form of a nearly mono-exponential time function after a delay of 5-7 s. 2. The time constants of the changes in the extracellular pH, PCO2, [Cl-] and [HCO-3] were in the range of 30-40 s. 3. The extracellular [HCO-3] increased markedly at an initial rate of 4.22 mmol.1(-1) . min-1 after 36 s. 4. This increase occurred almost simultaneously with a decrease in the extracellular [Cl-]. An [HCO-3]-[Cl-] exchange ratio was determined which very closely approached one. It is concluded that the brain extracellular bicarbonate concentration in respiratory acidosis increases because the H+ formed from the hydrated CO2 reacts with the intracellular buffers of brain cells, mainly glial cells, and HCO-3 inside the cell is formed and exchanged for Cl- outside the cell similar to the HCO-3/Cl- exchange which occurs between red cells and blood plasma during CO2 loading. The desc...Continue Reading

References

Dec 1, 1982·Pflügers Archiv : European journal of physiology·H R Ahmad, H H Loeschcke
Feb 1, 1990·Pflügers Archiv : European journal of physiology·L J TeppemaM Demedts
Dec 1, 1984·Respiration Physiology·J P KileyD E Millhorn
Feb 1, 1984·Respiration Physiology·D E MillhornJ P Kiley
Oct 1, 1984·Respiration Physiology·S Javaheri, J Weyne
Jun 13, 2006·High Altitude Medicine & Biology·Fabiola León-Velarde, Jean-Paul Richalet
Jul 8, 2008·Respiratory Physiology & Neurobiology·Maria Rivera-ChFabiola León-Velarde
Nov 5, 2004·American Journal of Physiology. Cell Physiology·Robert W PutnamNicola A Ritucci

Citations

Jan 1, 1976·Journal of Applied Physiology·D G Davies
Jan 1, 1978·Advances in Experimental Medicine and Biology·H R AhmadH H Woidtke
Aug 1, 1978·Pflügers Archiv : European journal of physiology·A LuttmannH H Loeschcke
Jan 1, 1978·Advances in Experimental Medicine and Biology·E E Nattie, L Romer
Jul 1, 1968·Archives internationales de physiologie et de biochimie·J WeyneI Leusen
Jan 1, 1973·Journal of Applied Physiology·H L Borison, L E McCarthy
Apr 1, 1973·Journal of Applied Physiology·H KazemiD C Shannon
May 24, 1974·Pflügers Archiv : European journal of physiology·T Middendorf, H H Loeschcke
Oct 1, 1967·Physiological Reviews·T H Maren
Apr 1, 1966·Annals of the New York Academy of Sciences·B K Siesjö, U Pontén
Mar 1, 1971·Life Sciences. Pt. 1: Physiology and Pharmacology·J L PannierI Leusen
Jan 1, 1969·Acta Neurologica Scandinavica·L Granholm, U Pontén
Dec 1, 1965·The American Journal of Physiology·A Roos
Jan 1, 1980·Annals of the New York Academy of Sciences·J O WiethJ Funder
Dec 1, 1982·Pflügers Archiv : European journal of physiology·H R Ahmad, H H Loeschcke
Jan 1, 1956·Pflügers Archiv : European journal of physiology·H H Loeschcke
Jan 1, 1958·The American Journal of Physiology·D A BRODIE, D M WOODBURY
Aug 1, 1958·The Journal of Clinical Investigation·G NICHOLS
Nov 1, 1960·Anesthesiology·C J LAMBERTSEN
Jul 1, 1961·Clinica Chimica Acta; International Journal of Clinical Chemistry·A van HEIJSTA H MAAS
Jul 1, 1961·Clinica Chimica Acta; International Journal of Clinical Chemistry·J A SCHNEIDERD Y HSIA
Sep 1, 1962·Experimental Neurology·A KOCHB L NEWMAN
Sep 1, 1963·The American Journal of Physiology·H KAZEMI, J C MITHOEFER
Dec 1, 1949·Journal of Cellular Physiology·G MARMONT

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