PMID: 6818519Dec 1, 1982

Fast bicarbonate-chloride exchange between plasma and brain extracellular fluid at maintained PCO2

Pflügers Archiv : European journal of physiology
H R Ahmad, H H Loeschcke

Abstract

The aim of this paper was to investigate the kinetics and mechanism of bicarbonate exchange at the blood-brain ECF barrier. The experiments were performed on anaesthetized and artificially ventilated cats in such a way that acid-base parameters of the brain extracellular fluid were continuously measured while an approximately rectangular increase in the arterial plasma bicarbonate concentration was produced at maintained PCO2. The results from such a preparation were: 1. A rapid increase in the brain extracellular bicarbonate concentration was observed in response to an i.v. bolus injection of 3 ml molar NaHCO3. The bolus was followed by a slow infusion of bicarbonate solution. The brain extracellular bicarbonate reached a new steady state within a minute. 2. This increase was almost simultaneously accompanied by a decrease in the extracellular chloride concentration. The HCO-3-Cl- exchange ratio very closely approached one. 3. The extracellular bicarbonate concentration in the brain, after an initial increase, returned towards control in spite of elevated arterial bicarbonate at maintained PCO2. 4. The results are discussed in terms of a 5-compartment model, where the extracellular fluid is interposed between the glial cells a...Continue Reading

References

Dec 1, 1982·Pflügers Archiv : European journal of physiology·H R Ahmad, H H Loeschcke
Oct 1, 1984·Respiration Physiology·S Javaheri, J Weyne
Apr 1, 1984·Respiration Physiology·R A SteinbrookV Fencl
Mar 1, 1984·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·W A Mutch, A J Hansen
Nov 5, 2004·American Journal of Physiology. Cell Physiology·Robert W PutnamNicola A Ritucci

Citations

Dec 1, 1975·Journal of Applied Physiology·S W Bledsoe, A H Mines
Jan 1, 1976·Journal of Applied Physiology·D G Davies
Apr 1, 1976·Journal of Applied Physiology·F M Hasan, H Kazemi
Jan 1, 1978·Advances in Experimental Medicine and Biology·H R AhmadH H Woidtke
Apr 1, 1975·The American Journal of Physiology·T F Hornbein, E G Pavlin
Apr 1, 1975·The American Journal of Physiology·E G Pavlin, Hornbein ttf
Apr 1, 1966·Annals of the New York Academy of Sciences·B K Siesjö, U Pontén
Aug 1, 1969·Scandinavian Journal of Clinical and Laboratory Investigation·B K Siesjö, A Kjällquist
Mar 1, 1971·Life Sciences. Pt. 1: Physiology and Pharmacology·J L PannierI Leusen
Jan 1, 1968·Journal of Applied Physiology·R S Kronenberg, S M Cain
Jul 1, 1969·Journal of Applied Physiology·V FenclJ A Broch
Jun 1, 1966·Acta Physiologica Scandinavica·U Pontén, B K Siesjö
Dec 1, 1982·Pflügers Archiv : European journal of physiology·H R Ahmad, H H Loeschcke
Jan 1, 1958·Pflügers Archiv : European journal of physiology·H H LoeschckeK H GERTZ
Nov 1, 1963·Journal of Applied Physiology·J W SEVERINGHAUSM M SINGER
Mar 1, 1965·The American Journal of Physiology·J R PAPPENHEIMERD HELD

Related Concepts

Chloride Ion Level
Blood - Brain Barrier Anatomy
Extracellular
Interphase
Extracellular Space
Brain
Interstitial
Extracellular Fluid
Carbonic Acid Ions
Neuroglia

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