Fast charge movements in skeletal muscle fibres from Rana temporaria

The Journal of Physiology
C A CollinsB A Suarez-Isla

Abstract

1. Fast charge movements were measured in cut skeletal muscle fibres from Rana temporaria.2. The initial time course of the current in response to a sudden displacement of the membrane potential from -110 to -60 mV was analysed in terms of an electrical equivalent circuit modified from Falk & Fatt (1964).3. The specific resistance in series with the sarcolemma was estimated as 7.4 Omega cm(2). The total capacity (surface sarcolemma plus tubular membrane) was estimated as 3.43 muF/cm(2).4. The asymmetry currents settling within 1 ms during depolarizing pulses of increasing size (on-response), from a holding potential around -120 mV, could be described in terms of a single exponential. The asymmetry currents after the pulses (off-response) exhibited at least two components.5. The integral of the on-response, Q(on), as a function of V(p), could be fitted using a function of the Boltzmann type. At the mid-point of the distribution curve, equal to -38 mV, the slope was 0.012 mV(-1). A saturating value of 28 pC was reached at 40 mV.6. The off-response to pulses not exceeding 3 ms exhibited two components. The first one had an exponential time course. The charge Q(off) associated with this fast component was always equal to Q(on).7. t...Continue Reading

Citations

Jan 1, 1985·Progress in Biophysics and Molecular Biology·J CailléO Rougier
Nov 17, 2001·The Journal of Physiology·F FranciniR Squecco
Feb 3, 2021·International Journal of Molecular Sciences·Caterina BernacchioniChiara Donati

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