Fast clonal expansion and limited neural stem cell self-renewal in the adult subependymal zone

Nature Neuroscience
Filippo CalzolariJovica Ninkovic

Abstract

We analyzed the progeny of individual neural stem cells (NSCs) of the mouse adult subependymal zone (SEZ) in vivo and found a markedly fast lineage amplification, as well as limited NSC self-renewal and exhaustion in a few weeks. We further unraveled the mechanisms of neuronal subtype generation, finding that a higher proportion of NSCs were dedicated to generate deep granule cells in the olfactory bulb and that larger clones were produced by these NSCs.

References

Jul 7, 2007·Science·Florian T MerkleArturo Alvarez-Buylla
Oct 5, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jovica NinkovicMagdalena Götz
Jul 8, 2008·Trends in Neurosciences·Pierre-Marie LledoArturo Alvarez-Buylla
Sep 2, 2008·Nature Neuroscience·Itaru ImayoshiRyoichiro Kageyama
May 18, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Brett A ShookJoanne C Conover
Feb 23, 2013·Proceedings of the National Academy of Sciences of the United States of America·Giovanna PontiArturo Alvarez-Buylla
Jun 12, 2013·Cell Stem Cell·Florian T Merkle, Kevin Eggan
Dec 24, 2013·Nature Neuroscience·Florian T MerkleArturo Alvarez-Buylla

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Citations

Jan 27, 2016·Neuroscience Letters·Colleen MahoneyNathaniel W Hartman
Apr 19, 2015·Stem Cell Research·Elias GebaraNicolas Toni
May 16, 2015·Glia·Emmanuel Than-Trong, Laure Bally-Cuif
Mar 26, 2016·Frontiers in Neuroscience·Felipe Ortega, Marcos R Costa
Oct 3, 2015·Cell Stem Cell·Allison M BondHongjun Song
Feb 19, 2016·Neurologia Medico-chirurgica·Yasushi Takagi
Apr 1, 2016·Scientific Reports·Jeff M FortinBrent A Reynolds
Jun 1, 2016·Frontiers in Neuroscience·Maria Figueres-Oñate, Laura López-Mascaraque
Jul 1, 2016·Nature Protocols·Joana S BarbosaJovica Ninkovic
Oct 22, 2016·Current Opinion in Cell Biology·Sangbum ParkKatie Cockburn
Sep 21, 2016·Wiley Interdisciplinary Reviews. Developmental Biology·Zayna ChakerFiona Doetsch
Sep 23, 2016·Scientific Reports·María Figueres-OñateLaura López-Mascaraque
Aug 5, 2016·Journal of Stroke·Zhenggang Zhang, Michael Chopp
Jun 15, 2016·Annual Review of Cell and Developmental Biology·Jonas Frisén
Nov 5, 2016·Cell·J Tiago GonçalvesFred H Gage
Nov 18, 2016·International Journal of Molecular Sciences·Rainer AkkermannPatrick Küry
Oct 16, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Ruilan ZhangMichael Chopp
Mar 17, 2017·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Vanessa Donega, Olivier Raineteau
Jan 10, 2018·Proceedings of the National Academy of Sciences of the United States of America·Onur BasakHans Clevers
Feb 14, 2018·Science·Magdalena Götz
Oct 4, 2018·Medical Sciences : Open Access Journal·Ugo TestaElvira Pelosi
Aug 23, 2019·The EMBO Journal·Thomas Wegleiter, Sebastian Jessberger
Dec 12, 2019·Wiley Interdisciplinary Reviews. Developmental Biology·Masato Nakafuku, Ángela Del Águila
May 29, 2016·Cold Spring Harbor Perspectives in Biology·Magdalena GötzDavid Petrik
May 30, 2017·Neural Regeneration Research·Rainer AkkermannPatrick Küry
May 17, 2018·Brain Plasticity·Avni BaserAna Martin-Villalba

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