Fast dispersible/slow releasing ibuprofen tablets

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
Adamo FiniCarlos Alberto Fonseca de Moraes

Abstract

Eight formulations were developed containing ibuprofen in the form of orally disintegrating tablets. To prevent bitter taste and side effects of the drug, the drug was associated with Phospholipon 80H, a saturated lecithin, by wet granulation. The granules were then coated using different film forming agents (Kollicoat SR 30, Amprac 01, Kollidon 90F, Eudragit RD 100) obtaining four lots 1-4. Coated granules were then formulated with a sweetener (Aspartame), a mannitol-based diluent (Pearlitol SD 200) and Kollidon CL (1-4K) or Explotab (1-4E) were added as superdisintegrants and compacted under low compression force. The eight lots of tablets, 1-4K and 1-4E, were assessed if suitable as oral disintegrating tablets by determination of a range of technological parameters. Wetting and disintegregation time matched with the requirements of EP IV Ed., for almost all these formulations. Dissolution profiles suggested that the combined action of the hydrophobic lecithin and the coating delay the release of the drug from tablets with respect to when it is free or in the form of simple granules. By an appropriate combination of excipients it was thus possible to obtain orally disintegrating tablets and a delayed release of ibuprofen usin...Continue Reading

References

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Jul 14, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·A E Clausen, A Bernkop-Schnürch
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Apr 1, 2003·Pharmaceutical Development and Technology·Chuanbin Wu, James W McGinity
Jan 22, 2005·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Gelsys Ananay Gonzalez NovoaJouko Yliruusi
Feb 12, 2005·Drug Development and Industrial Pharmacy·Piera Di MartinoPascal Wehrlé

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Citations

Apr 23, 2010·Pharmaceutical Research·Gert FrickerChristel Müller-Goymann
Oct 1, 2013·International Journal of Pharmaceutics·K KolterR Bodmeier
Apr 21, 2010·AAPS PharmSciTech·Yosra Shaaban R ElnaggarAbd Elazim R Ebian
Jun 21, 2011·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Bhatu P Badgujar, Atish S Mundada
Jul 1, 2011·International Journal of Pharmaceutical Investigation·Karan MalikSandeep Arora
Apr 13, 2013·International Journal of Pharmaceutical Investigation·Amish Ashvinkumar Dangi, Prakash Bhikhabhai Zalodiya
Jun 27, 2013·Indian Journal of Pharmaceutical Sciences·V SankarS Karthik
Mar 10, 2012·Drug Development and Industrial Pharmacy·Qionghua WeiLibiao Luan
Apr 4, 2015·International Journal of Pharmaceutics·Ketsia YekpeAntoine Cournoyer
May 18, 2012·Pharmaceutical Development and Technology·Shivaan CooppanViness Pillay
Nov 5, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sally GittingsPavel Gershkovich
Jul 8, 2017·CNS Spectrums·Andrew J Cutler, Gregory W Mattingly
Feb 19, 2010·Pharmaceutical Development and Technology·Omaima A SammourAyman G Mowafy
Feb 20, 2020·Drug Delivery and Translational Research·Mohamed Ahmed El-NabarawiAmani M El Sisi
Dec 23, 2020·Chemistry and Physics of Lipids·Surojit BanerjeeVikas Anand Saharan
Mar 23, 2019·Molecular Pharmaceutics·Alexander KeeleyCatherine Tuleu

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