Fast dissolving drug delivery membrane based on the ultra-thin shell of electrospun core-shell nanofibers

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
Jiao-Jiao LiXiang-Liang Yang

Abstract

Structural nanocomposites that provide fast dissolving drug release profiles are highly in demand in pharmaceutics. In this study, a poorly water-soluble drug such as quercetin or tamoxifen citrate (TC) was selected as a model active pharmaceutical ingredient. Core-shell nanofibers with ultra-thin shells were designed and prepared using modified coaxial electrospinning. Polyvinylpyrrolidone (PVP) K90 or Polycaprolactone (PCL) was selected as core. The drugs and PVP K10 were selected as shell. All types of solutions can be used as the shell fluids in modified coaxial process regardless of their electrospinnability, which means the increasing functional ingredients and unspinnable matrix can be processed. Evaluations via SEM and TEM demonstrated that the core-shell nanofibers had linear morphology with a shell thickness smaller than 100 nm. XRD and FTIR results showed that the model drug was distributed in the polymeric matrix amorphously and that PVP K10 had good compatibility with quercetin or TC. In vitro dissolution tests suggested that the core-shell nanofibers with ultra-thin shells released the loaded cargoes in the dissolution media within 1 min. The present investigation paved a new way for implementing the modified coax...Continue Reading

Citations

Feb 26, 2019·Journal of Food Science·José Agustín Tapia-HernándezFrancisco Rodríguez-Félix
Feb 5, 2019·Current Drug Delivery·Heather A E BensonMichael S Roberts
May 13, 2020·Drug Development and Industrial Pharmacy·Fatmanur Tuğcu-DemirözFüsun Acartürk
Apr 10, 2019·Polymers·Chee Hong Takahiro YewBelinda Pingguan-Murphy
Oct 19, 2019·Drug Development and Industrial Pharmacy·Shreya ThakkarManju Misra
Apr 17, 2019·Nanomaterials·S M Shatil ShahriarYong-Kyu Lee
Dec 8, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Amane ShioharaNicolas H Voelcker
Mar 11, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Fatmanur Tuğcu-DemirözFüsun Acartürk
Jul 2, 2019·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Špela Zupančič
May 12, 2021·ACS Applied Materials & Interfaces·Tao LuChaobo Huang
May 15, 2021·International Journal of Pharmaceutics·Mohammad Reza ZareKamiar Zomorodian

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