Fast eye movement initiation of ocular torsion in mesodiencephalic lesions

Annals of Neurology
C R BentleyP Riordan-Eva

Abstract

Three patients with episodic ocular torsion and skew deviation due to mesodiencephalic lesions were studied by using binocular three-dimensional scleral search coils. The conjugate ocular torsion (upper pole of each eye rotating toward the side of the brainstem lesion) was initiated by a torsional fast eye movement. During prolonged episodes, torsional nystagmus was also present. Cessation of the ocular torsion and skew deviation occurred by slow eye movements with exponentially decreasing velocities in 2 patients, and by multiple fast torsional movements in 1 patient. In 1 patient, the abnormal eye movements were temporally linked to dystonic movements in the limbs on the side opposite the brainstem lesion. The occurrence of skew deviation with conjugate ocular torsion in brainstem lesions has been attributed to functional asymmetry in vestibular pathways responsible for the slow-phase compensatory eye movement response to roll. In comparison, the findings in our patients show that in mesodiencephalic lesions conjugate ocular torsion with skew deviation may be generated by torsional fast eye movements, indicating activation of the burst cells of the rostral interstitial nucleus of the medial longitudinal fasciculus.

References

Jul 1, 1979·Annals of Neurology·G M HalmagyiW P Gibson
Aug 1, 1977·Archives of Ophthalmology·H E RabinovitchT O Sylvester
Jul 11, 1975·Experimental Brain Research·M P Stryker, P H Schiller
Aug 1, 1992·Brain : a Journal of Neurology·L LopezE P du Boulay
Aug 1, 1992·Journal of Neurophysiology·J D Crawford, T Vilis
Jan 1, 1991·Experimental Brain Research·I S CurthoysG M Halmagyi
Jan 1, 1991·Acta Oto-laryngologica. Supplementum·G M HalmagyiM Dieterich
Jan 1, 1989·Experimental Brain Research·T VillisV Henn
Oct 1, 1989·Brain : a Journal of Neurology·M DieterichW Fries
Sep 1, 1988·Annals of Neurology·M J Morrow, J A Sharpe
Aug 1, 1994·Brain : a Journal of Neurology·G M HalmagyiM J Todd
Mar 1, 1993·Neurosurgery·G I WolfeS L Galetta
Feb 23, 1996·Neuroscience Letters·K Jauregui-RenaudM A Gresty
Jan 1, 1997·Annals of Neurology·P Riordan-EvaM A Gresty

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Citations

Feb 24, 2001·Medical & Biological Engineering & Computing·A IijimaN Ishikawa
Apr 19, 2002·Annals of the New York Academy of Sciences·Ulrich BuuttnerChristoph Helmchen
Feb 28, 2006·Survey of Ophthalmology·Michael C BrodskyThomas Brandt
Jan 11, 2002·Neurological Research·Federico C ViñasFernando G Diaz
Jun 14, 2015·Annales d'endocrinologie·Lucie AbouafMaud Lebas
Sep 27, 2002·British Medical Bulletin·Adolfo M Bronstein
Feb 8, 2000·Current Opinion in Ophthalmology·M F Walker, D S Zee
Feb 8, 2000·Current Opinion in Ophthalmology·J B Kerrison

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