Fast HPLC-MS/MS Method for Determining Penicillin Antibiotics in Infant Formulas Using Molecularly Imprinted Solid-Phase Extraction

Journal of Analytical Methods in Chemistry
Mónica Díaz-BaoP Regal

Abstract

The dairy cattle may suffer from different infections relatively often, but the inflammation of the mammary gland is very important to the farmer. These infections are frequently treated with penicillin antimicrobial drugs. However, their use may result in the presence of residues in animal products, such as milk powder and/or infant formulas, and it represents a potential risk for consumers. To monitor this, the EU has defined safe maximum residue limits (MRLs) through Commission Regulation (EU) number 37/2010. Although LC-MS is a trustful option for confirmation and quantification of antibiotics, the analysis of real samples with complex matrices frequently implies previous clean-up steps. In this work, precipitation polymerization has been used and different molecularly imprinted polymer (MIP) sorbents were tested and optimized for the fast and simultaneous solid-phase extraction (MISPE) of eight common penicillins (ampicillin, amoxicillin, oxacillin, penicillin G, penicillin V, cloxacillin, dicloxacillin, and nafcillin). The extracts were analyzed using liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) and the applicability of these polymers as sorbents for the extraction of penicillins at MRL levels in m...Continue Reading

References

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Citations

Sep 8, 2015·Analytical and Bioanalytical Chemistry·Javier L UrracaMaria C Moreno-Bondi
Feb 3, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dimitrios Bitas, Victoria Samanidou
Aug 4, 2020·Critical Reviews in Food Science and Nutrition·Seyed Amin KhatibiMohammad Reza Siahi-Shadbad
May 18, 2020·Environmental Monitoring and Assessment·Cansu Ilke KuruSinan Akgöl
Jul 23, 2020·Biotechnology Letters·Tannu KharewalVikas Hooda
Sep 25, 2018·Chemical Reviews·Joseph J BelBruno

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