Fast multi-dimensional NMR by minimal sampling

Journal of Magnetic Resonance
Eriks Kupce, Ray Freeman

Abstract

A new scheme is proposed for very fast acquisition of three-dimensional NMR spectra based on minimal sampling, instead of the customary step-wise exploration of all of evolution space. The method relies on prior experiments to determine accurate values for the evolving frequencies and intensities from the two-dimensional 'first planes' recorded by setting t1=0 or t2=0. With this prior knowledge, the entire three-dimensional spectrum can be reconstructed by an additional measurement of the response at a single location (t1( *),t2( *)) where t1( *) and t2( *) are fixed values of the evolution times. A key feature is the ability to resolve problems of overlap in the acquisition dimension. Applied to a small protein, agitoxin, the three-dimensional HNCO spectrum is obtained 35 times faster than systematic Cartesian sampling of the evolution domain. The extension to multi-dimensional spectroscopy is outlined.

References

Sep 26, 2000·Journal of Magnetic Resonance·J ChenA J Shaka
Jan 30, 2003·Journal of the American Chemical Society·Seho Kim, Thomas Szyperski
Jul 11, 2003·Journal of Magnetic Resonance·Eriks Kupce, Ray Freeman
Nov 13, 2003·Journal of the American Chemical Society·Eriks Kupce, Ray Freeman
May 20, 2004·Journal of the American Chemical Society·Eriks Kupce, Ray Freeman
Mar 23, 2005·Journal of Magnetic Resonance·Eriks Kupce, Ray Freeman
Jul 27, 2005·Proceedings of the National Academy of Sciences of the United States of America·Sebastian HillerGerhard Wider
Sep 30, 2005·Journal of the American Chemical Society·Daniel Malmodin, Martin Billeter
Feb 21, 2006·Journal of Magnetic Resonance·Krzysztof KazimierczukIgor Zhukov
May 4, 2006·Journal of the American Chemical Society·Eriks Kupce, Ray Freeman
Jun 23, 2006·Journal of Biomolecular NMR·Francesco FioritoKurt Wüthrich
Oct 13, 2006·Journal of Biomolecular NMR·Krzysztof KazimierczukIgor Zhukov
Oct 31, 2006·Journal of Magnetic Resonance·Brian E Coggins, Pei Zhou

❮ Previous
Next ❯

Citations

Feb 2, 2012·Progress in Nuclear Magnetic Resonance Spectroscopy·Franz DalitzGisela Guthausen
Feb 3, 2009·Journal of Magnetic Resonance·Krzysztof KazimierczukWiktor Koźmiński
Jan 13, 2009·Journal of Magnetic Resonance·Christopher Kumar AnandAnuroop Sharma
Oct 7, 2008·Journal of Magnetic Resonance·John M Gledhill, A Joshua Wand
Oct 7, 2010·Biophysical Journal·Yingnan JiangMaor Bar-Peled
Sep 20, 2011·Journal of Magnetic Resonance·Ēriks Kupče, Ray Freeman
Oct 3, 2009·Journal of the American Chemical Society·Wolfgang BermelRoberta Pierattelli

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Magnetic Resonance
Brian E Coggins, Pei Zhou
Journal of Magnetic Resonance
Eriks Kupce, Ray Freeman
Journal of Magnetic Resonance
Krzysztof KazimierczukIgor Zhukov
Journal of Biomolecular NMR
Krzysztof KazimierczukIgor Zhukov
© 2021 Meta ULC. All rights reserved