PMID: 6350243Sep 1, 1983

Fast neutron irradiation of metastatic cervical adenopathy: the results of a randomized RTOG study

International Journal of Radiation Oncology, Biology, Physics
T W GriffinA Rodriguez-Antunez

Abstract

Between 1977 and 1982, 199 evaluable patients with measurable cervical adenopathy were entered on a prospective, randomized RTOG study evaluating the use of fast neutrons in treatment of advanced, inoperable squamous cell carcinomas of the head and neck region. One hundred-eleven patients were randomized to receive mixed beam radiation therapy, and 88 were randomized to the photon control treatment. The complete response rates were 86% for mixed beam vs 75% for photons for Stage N1 nodes, 62% for mixed beam vs 48% for photons for Stage N2 nodes, and 63% for mixed beam vs 53% for photons for N3 nodes. The percents of patients remaining free of their adenopathy for two years were 78% for mixed beam vs 55% for photons for Stage N1 nodes, 39% for both mixed beam and photons for N2 nodes and 24% for mixed beam vs 13% for photons for N3 nodes. The median disease-free status was 20.3 months for mixed beam treated patients and 6.4 months for photon-treated patients. Patients who had clearance of cervical adenopathy survived significantly longer than those who did not.

Citations

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Related Concepts

Squamous Cell Carcinoma
Clinical Trials
Elementary Particles
Fast Neutrons
Cancer of Neck
Lymphatic Metastasis
TNM Staging System
Neutrons
Randomization

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