PMID: 8949778Jan 1, 1996Paper

Fast neutron radiotherapy and boron neutron capture therapy: application to a human melanoma test system

Bulletin du cancer. Radiothérapie : journal de la Société française du cancer : organe de la société française de radiothérapie oncologique
G E LaramoreD S Wilbur

Abstract

Fast neutron radiotherapy has proven to be an effective form of treatment in a selected subset of tumors (salivary gland tumors, sarcomas, and locally-advanced prostate cancer), but has not proven to be more beneficial than conventional photon irradiation for the majority of tumor types upon which it has been tested. Normal tissue tolerance limits preclude simply further escalating the neutron dose. Boron neutron capture (BNC) provides a way of selectively augmenting the radiation dose to the tumor. This process is described, and cell culture and animal model data reviewed. An irradiation configuration was developed where an enhancement of 2.10(-3) for 1 microgram of 10B per gram of tissue was achieved. This is similar to the enhancement achievable in the center of a 20 x 20 cm field envisioned for future applications such as metastases in the brain. A boron concentration of 50 micrograms per gram of tumor tissue leads to a 10% increase in the delivered physical dose in this scenario. The first human test of BNC enhancement of a fast neutron radiotherapy beam using pharmacologically-acceptable doses of orally-administered, 10B-enriched, L-paraboronophenylalanine is reported. An enhancement of tumor response was demonstrated for...Continue Reading

References

Nov 15, 1989·Cancer·G SchmittN Zamboglou
Mar 30, 1994·International Journal of Radiation Oncology, Biology, Physics·G E LaramoreS Brossard
Oct 15, 1940·Proceedings of the National Academy of Sciences of the United States of America·P A ZahlJ R Dunning
Mar 15, 1940·Proceedings of the National Academy of Sciences of the United States of America·P G Kruger

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Citations

Nov 14, 2001·Journal of Photochemistry and Photobiology. B, Biology·C FabrisG Roncucci
May 8, 1998·Molecular Medicine Today·M F Hawthorne
Jan 8, 2016·Physics in Medicine and Biology·Gregory B MoffittTatjana Jevremovic

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