PMID: 3102414Feb 1, 1987

Fast neutron therapy for squamous cell carcinoma in the head and neck region: results of a randomized trial

International Journal of Radiation Oncology, Biology, Physics
W DuncanJ R Williams

Abstract

A randomized trial of fast neuron therapy compared with 4MV photons for patients with head and neck cancer is reported. One hundred and sixty-eight patients were recruited between 1977 and 1984. The minimum follow-up is 2 years. Three patients were withdrawn before treatment began. Eighty-five were allocated to neutron therapy and 80 to receive photon therapy. All patients had squamous cell cancers in one of four primary sites: oral cavity, oropharynx, larynx, and hypopharynx. Local tumor control was similar in both groups: 44.7% after neutrons and 45.0% after photons. Salvage surgery was performed on 18 patients in each treatment group for residual or recurrent cancer. Acute radiation reactions of the mucous membranes were significantly more severe after photons. The number of patients with serious late reactions was greater after neutron therapy but the difference was not statistically significant. There were six deaths related to late morbidity after neutron therapy but none after photon therapy. Survival was better after photon therapy but the difference compared with the neutron group failed to reach statistical significance. When intercurrent deaths are excluded, the difference is less marked. Photon therapy was clearly b...Continue Reading

References

Mar 1, 1979·The British Journal of Radiology·J R WilliamsC J Parnell
Feb 1, 1985·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·B J MijnheerA Wambersie
Dec 1, 1984·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·W DuncanG R Kerr
Jan 1, 1980·The British Journal of Radiology·D E BonnettC J Parnell
Dec 1, 1982·International Journal of Radiation Oncology, Biology, Physics·L Cohen

Citations

Oct 1, 1995·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·K PigottM I Saunders
Oct 23, 1997·International Journal of Radiation Oncology, Biology, Physics·A S GlicksmanR Probst
Nov 25, 1989·BMJ : British Medical Journal·J S Tobias
Jan 18, 1992·Lancet·J S Tobias
Dec 1, 1994·International Journal of Radiation Oncology, Biology, Physics·A S GlicksmanH J Wanebo
Jan 1, 1996·Bulletin du cancer. Radiothérapie : journal de la Société française du cancer : organe de la société française de radiothérapie oncologique·K L LindsleyT W Griffin
Sep 24, 2004·International Journal of Radiation Oncology, Biology, Physics·Jun-Etsu MizoeOrganizing Committee for the Working Group for Head-And-Neck Cancer
Feb 9, 1991·BMJ : British Medical Journal·J M Kay
Feb 9, 1991·BMJ : British Medical Journal
Jan 1, 1994·Acta Oncologica·H Svensson, T Landberg
Jan 1, 1994·Acta Oncologica·W Duncan
Dec 15, 2010·The Cochrane Database of Systematic Reviews·Anne-Marie GlennyCSROC Expert Panel
Jun 1, 1992·International Journal of Radiation Biology·R A BrittenJ H Peacock
May 22, 2001·Head & Neck·H StruikmansI van der Tweel

Related Concepts

Squamous Cell Carcinoma
Clinical Trials
Fast Neutrons
Cancer of Neck
Neutrons
Betatrons
Radiotherapy, Megavolt
Randomization

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.