PMID: 8949763Jan 1, 1996Paper

Fast neutron therapy in treatment of soft tissue sarcoma--the Berlin-Buch study

Bulletin du cancer. Radiothérapie : journal de la Société française du cancer : organe de la société française de radiothérapie oncologique
M SteingräberU Jahn

Abstract

From 1975-1994, 221 adult patients with a total of 232 radiation sites for soft tissue sarcomas were irradiated with fast neutrons with a mean energy of 6.2 MeV in Berlin-Buch/Dresden-Rossendorf. The tumour dose ranged between 6 and 12 Gy and was limited by the low dose penetration of the neutron beam. A local control rate of 66% was obtained. The local control was affected by the tumour differentiation, residual status and histological subtype. Severe fibrosis of the subcutaneous tissues occurred in 40% usually after 2 years. No serious general side effects occurred. To optimize neutron therapy, a high energy clinically-based cyclotron with a fully rotational gantry and a multileaf collimator should be utilized. It seems that patients with locally advanced and well differentiated sarcomas can benefit from this therapy.

References

Aug 1, 1985·Cancer·J E Tepper, H D Suit

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Citations

Jul 8, 1999·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·F J ProttN Willich
May 31, 2001·International Journal of Radiation Oncology, Biology, Physics·D L SchwartzG E Laramore
Mar 1, 2012·Surgical Oncology Clinics of North America·Thomas F Delaney
Mar 27, 1999·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·H T EichH Sack

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