Fast nongenomic effects of steroids on synaptic transmission and role of endogenous neurosteroids in spinal pain pathways.

Journal of Molecular Neuroscience : MN
Rémy SchlichterPierrick Poisbeau

Abstract

Steroids exert long-term modulatory effects on numerous physiological functions by acting at intracellular/nuclear receptors influencing gene transcription. Steroids and neurosteroids can also rapidly modulate membrane excitability and synaptic transmission by interacting with ion channels, that is, ionotropic neurotransmitter receptors or voltage-dependent Ca2+ or K+ channels. More recently, the cloning of a plasma membrane-located G protein-coupled receptor for progestins in various species has suggested that steroids/neurosteroids could also influence second-messenger pathways by directly interacting with specific membrane receptors. Here we review the experimental evidence implicating steroids/neurosteroids in the modulation of synaptic transmission and the evidence for a role of endogenously produced neurosteroids in such modulatory effects. We present some of our recent results concerning inhibitory synaptic transmission in lamina II of the spinal cord and show that endogenous 5alpha-reduced neurosteroids are produced locally in lamina II and modulate synaptic gamma-aminobutyric acid A(GABAA) receptor function during development, as well as during inflammatory pain. The production of 5alpha-reduced neurosteroids is contro...Continue Reading

Citations

Nov 9, 2007·Annual Review of Physiology·U Benjamin KauppIngo Weyand
Apr 1, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Xiaochun Jin, Joe Henry Steinbach
Jul 6, 2014·Frontiers in Cellular Neuroscience·Pierrick PoisbeauMichael Schumacher
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