Mar 12, 2004

Fast pathway-His bundle connections in the rabbit heart

Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing
Eugene Patterson, Benjamin J Scherlag


The incidence and the physiologic roles for direct fast pathway-His bundle connections were examined in 102 rabbit hearts. Extracellular bipolar and intracellular microelectrode recordings were made from the superfused rabbit AV junction. In 13 of 27 preparations demonstrating anterior extensions of the fast pathway, the retrograde HA ERP and 2:1 block cycle length were shortened (128 +/- 12 and 145 +/- 5 msec, respectively) versus the remaining 89 preparations (178 +/- 15 and 185 +/- 10 msec, respectively, p < 0.01). The former values were similar to the ERP and 2:1 block cycle length of fast pathway transitional cells (128 +/- 23 and 141 +/- 4 msec, respectively), suggestive of a direct fast pathway-His bundle connection. A deflection recorded between the A and H potentials of the His bundle electrogram could be dissociated from both atrial and His bundle activation. Intracellular microelectrode recordings and light microscopy confirmed the deflection to be an accessory pathway consisting of an anterior extension of fast pathway transitional cells connecting the atrium and His bundle. Transection along the AV groove anterior to the compact AV node ( N = 5) increased the retrograde ERP and Wenckebach block cycle length by seve...Continue Reading

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Mentioned in this Paper

Biochemical Pathway
Implantable Stimulation Electrodes
Accessory Atrioventricular Bundle
Left Bundle Branch of His
Aphasia, Broca
Accessory Atrioventricular Bundle (Body Structure)
Chinchilla Rabbits

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