Fast processes of nanoparticle blood clearance: Comprehensive study.

Journal of Controlled Release : Official Journal of the Controlled Release Society
I V ZelepukinMaxim P Nikitin

Abstract

Blood circulation is the key parameter that determines the in vivo efficiency of nanoagents. Despite clinical success of the stealth liposomal agents with their inert and shielded surfaces, a great number of non-stealth nanomaterials is being developed due to their potential of enhanced functionality. By harnessing surface phenomena, such agents can offer advanced control over drug release through intricately designed nanopores, catalysis-propelled motion, computer-like analysis of several disease markers for precise target identification, etc. However, investigation of pharmacokinetic behavior of these agents becomes a great challenge due to ultra-short circulation (usually around several minutes) and impossibility to use the invasive blood-sampling techniques. Accordingly, the data on circulation of such agents has been scarce and irregular. Here, we demonstrate high-throughput capabilities of the developed magnetic particle quantification technique for nanoparticle circulation measurements and present a comprehensive investigation of factors that affect blood circulation of the non-stealth nanoparticles. Namely, we studied the following 9 factors: particle size, zeta-potential, coating, injection dose, repetitive administrat...Continue Reading

Citations

Feb 7, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Ivan V ZelepukinSergey M Deyev
Dec 17, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Aziz B MirkasymovSergey M Deyev
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Victoria Olegovna ShipunovaSergey Mikhailovich Deyev
Jul 13, 2021·ACS Nano·Ivan V ZelepukinMaxim P Nikitin

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