Fast progression of recombinant human myelin/oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis in marmosets is associated with the activation of MOG34-56-specific cytotoxic T cells

The Journal of Immunology : Official Journal of the American Association of Immunologists
Yolanda S KapBert A 't Hart

Abstract

The recombinant human (rh) myelin/oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE) model in the common marmoset is characterized by 100% disease incidence, a chronic disease course, and a variable time interval between immunization and neurological impairment. We investigated whether monkeys with fast and slow disease progression display different anti-MOG T or B cell responses and analyzed the underlying pathogenic mechanism(s). The results show that fast progressor monkeys display a significantly wider specificity diversification of anti-MOG T cells at necropsy than slow progressors, especially against MOG(34-56) and MOG(74-96). MOG(34-56) emerged as a critical encephalitogenic peptide, inducing severe neurological disease and multiple lesions with inflammation, demyelination, and axonal injury in the CNS. Although EAE was not observed in MOG(74-96)-immunized monkeys, weak T cell responses against MOG(34-56) and low grade CNS pathology were detected. When these cases received a booster immunization with MOG(34-56) in IFA, full-blown EAE developed. MOG(34-56)-reactive T cells expressed CD3, CD4, or CD8 and CD56, but not CD16. Moreover, MOG(34-56)-specific T cell lines displayed specifi...Continue Reading

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Citations

Mar 5, 2011·British Journal of Pharmacology·Cris S ConstantinescuBruno Gran
Oct 18, 2011·Journal of Neuropathology and Experimental Neurology·Yolanda S KapBert A 't Hart
Oct 21, 2011·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·S Anwar JagessarCris S Constantinescu
Oct 3, 2009·Annals of Neurology·Stefano PluchinoGianvito Martino
Jan 27, 2010·International Reviews of Immunology·Fang Zhou
Apr 2, 2009·Journal of Neuropathology and Experimental Neurology·Bert A 't Hart, Luca Massacesi
Aug 9, 2012·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·S Anwar JagessarBert A 't Hart
Jul 15, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·S Anwar JagessarBert A 't Hart
May 16, 2017·Journal of Neuropathology and Experimental Neurology·Jordon DunhamYolanda S Kap
Jun 14, 2017·Multiple Sclerosis Journal - Experimental, Translational and Clinical·Bert A 't Hart, Yolanda S Kap
May 24, 2017·Frontiers in Immunology·Patrick PeschlMarkus Reindl
Aug 12, 2010·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Yolanda S KapBert A 't Hart
Aug 27, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yolanda S KapBert A 't Hart
Oct 15, 2009·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Yolanda S KapBert A 't Hart
Mar 20, 2013·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·S Anwar JagessarBert A 't Hart
Jul 4, 2013·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Krista G HaanstraBert A 't Hart
Jun 7, 2017·Veterinary Pathology·Lev StimmerChé Serguera
Oct 21, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yolanda S KapBert A 't Hart
May 23, 2015·Annals of Clinical and Translational Neurology·Bert A 't HartBruno Gran
Oct 16, 2018·Multiple Sclerosis : Clinical and Laboratory Research·David John BurrowsArshad Majid
Feb 8, 2019·Multiple Sclerosis : Clinical and Laboratory Research·Jennifer A LefeuvrePascal Sati
May 28, 2021·EBioMedicine·Bert A 't HartJeroen J G Geurts
Jun 23, 2021·Annals of Clinical and Translational Neurology·Bert A 't HartJeroen J G Geurts
Jun 26, 2021·Current Protocols·Paul Smith

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