Fast progressive lower motor neuron disease is an ALS variant: A two-centre tract of interest-based MRI data analysis

NeuroImage. Clinical
Hans-Peter MüllerJan Kassubek

Abstract

The criteria for assessing upper motor neuron pathology in pure lower motor neuron disease (LMND) still remain a major issue of debate with respect to the clinical classification as an amyotrophic lateral sclerosis (ALS) variant. The study was designed to investigate white matter damage by a hypothesis-guided tract-of-interest-based approach in patients with LMND compared with healthy controls and ´classical´ ALS patients in order to identify in vivo brain structural changes according to the neuropathologically defined ALS affectation pattern. Data were pooled from two previous studies at two different study sites (Ulm, Germany and Milano, Italy). DTI-based white matter integrity mapping was performed by voxelwise statistical comparison and by a tractwise analysis of fractional anisotropy (FA) maps according to the ALS-staging pattern for 65 LMND patients (clinically differentiated in fast and slow progressors) vs. 92 matched controls and 101 ALS patients with a 'classical' phenotype to identify white matter structural alterations. The analysis of white matter structural connectivity by regional FA reductions demonstrated the characteristic alteration patterns along the CST and also in frontal and prefrontal brain areas in LMND...Continue Reading

Citations

Apr 10, 2018·Expert Review of Neurotherapeutics·Federica AgostaMassimo Filippi
Mar 29, 2019·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·F AgostaM Filippi
Jan 16, 2020·Expert Review of Neurotherapeutics·Jan Kassubek, Hans-Peter Müller
Jul 25, 2019·Current Opinion in Neurology·Jan Kassubek, Marco Pagani
Sep 5, 2020·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Francesca TrojsiGioacchino Tedeschi
Oct 16, 2018·Frontiers in Neuroscience·Hans-Peter Müller, Jan Kassubek
Dec 14, 2018·NeuroImage. Clinical·Giorgia QuerinPierre-François Pradat
Sep 6, 2020·Neurobiology of Disease·Suvi HäkkinenSuzee E Lee

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Methods Mentioned

BETA
PMA

Software Mentioned

Tensor Imaging and Fiber Tracking ( TIFT )
TFAS
TBSS
WBSS

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