Fast prospective registration of in vivo MR images of trabecular bone microstructure in longitudinal studies.

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Chamith S RajapakseFelix W Wehrli

Abstract

In micro-MRI studies of trabecular bone designed to evaluate structural changes in response to intervention, follow-up scan volumes do not typically align exactly with the baseline scan volumes due to the orientation and placement of the anatomic location, here the distal tibia, relative to the scanner coordinates. Failure of accurate registration of the follow-up to the baseline images introduces errors due to the inherent anisotropy in the trabecular network and anisotropic voxel size. In this work it is shown that these limitations can be overcome by incorporating on-line prospective registration into the data acquisition protocol. The technique is based on a short 3D localizer scan of 1 mm isotropic resolution prior to acquiring the high-resolution images. During the follow-up exam, localizer images are registered on-site with an algorithm relying on a fast Fourier transform for maximizing the correlation between baseline and follow-up localizers. Transformation parameters obtained in this manner are then fed into the scanner software so that the imaging slab for the high-resolution follow-up images is automatically positioned consistent with that of the baseline scan. Based on phantom and human subject studies it is shown ...Continue Reading

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Citations

Mar 6, 2010·Annals of Biomedical Engineering·Oleg MuseykoKlaus Engelke
May 7, 2011·Magnetic Resonance Imaging·Janet GoldensteinSharmila Majumdar
Jul 9, 2010·Radiologic Clinics of North America·Roland KrugThomas M Link
Apr 2, 2009·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Chamith S RajapakseFelix W Wehrli
Mar 25, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Julio Carballido-GamioRoland Krug
Apr 8, 2010·Journal of Magnetic Resonance Imaging : JMRI·Yaotang WuMelvin J Glimcher
May 1, 2010·Journal of Magnetic Resonance Imaging : JMRI·Michael Jeffrey WaldFelix Werner Wehrli
Dec 20, 2008·Journal of Magnetic Resonance Imaging : JMRI·Jeremy F MaglandFelix W Wehrli
Dec 25, 2009·International Journal of Computer Assisted Radiology and Surgery·Sergiy MilkoTimor Kadir
Dec 15, 2020·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Chamith S RajapakseFelix W Wehrli

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