Fast range-corrected proton dose approximation method using prior dose distribution.

Physics in Medicine and Biology
Peter C ParkLei Dong

Abstract

For robust plan optimization and evaluation purposes, one needs a computationally efficient way to calculate dose distributions and dose-volume histograms (DVHs) under various changes in the variables associated with beam delivery and images. In this study, we report an approximate method for rapid calculation of dose when setup errors and anatomical changes occur during proton therapy. This fast dose approximation method calculates new dose distributions under various circumstances based on the prior knowledge of dose distribution from a reference setting. In order to validate the method, we calculated and compared the dose distributions from our approximation method to the dose distributions calculated from a clinically commissioned treatment planning system which was used as the ground truth. The overall accuracy of the proposed method was tested against varying degrees of setup error and anatomical deformation for selected patient cases. The setup error was simulated by rigid shifts of the patient; while the anatomical deformation was introduced using weekly acquired repeat CT data sets. We evaluated the agreement between the dose approximation method and full dose recalculation using a 3D gamma index and the root-mean-squa...Continue Reading

References

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Citations

May 3, 2013·Medical Physics·Joey P CheungLei Dong
Apr 17, 2016·International Journal of Radiation Oncology, Biology, Physics·Catarina VeigaBoon-Keng Kevin Teo
May 22, 2013·International Journal of Radiation Oncology, Biology, Physics·Peter C ParkLei Dong
Feb 25, 2015·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Heng LiRonald Zhu
Nov 13, 2018·Physics in Medicine and Biology·Jan UnkelbachHuijun Xu
Oct 6, 2017·Physics in Medicine and Biology·H P WieserM Bangert
May 27, 2016·Physics in Medicine and Biology·Zoltán PerkóDanny Lathouwers

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