PMID: 9188097Mar 1, 1997Paper

Fast receptor-induced formation of glycerophosphoinositol-4-phosphate, a putative novel intracellular messenger in the Ras pathway

Molecular Biology of the Cell
M FalascaD Corda

Abstract

Glycerophosphoinositols are phosphoinositide metabolites whose levels are constitutively elevated in Ras-transformed cells. Here, we show that one of these compounds, glycerophosphoinositol-4-phosphate (GroPIns-4-P) responds acutely to the stimulation of the epidermal growth factor receptor, with a fast, massive and transient increase. The mechanism leading to GroPIns-4-P formation involves the activation of phosphoinositide-3 kinase and the small GTP-binding protein Rac, since GroPIns-4-P was neither formed in cells expressing the dominant negative form of Rac nor in cells treated with the phosphoinositide-3 kinase inhibitor wortmannin. GroPIns-4-P has been previously shown to inhibit adenylyl cyclase. Accordingly, epidermal growth factor also decreased the basal, cholera toxin-stimulated, and forskolin-stimulated cyclic AMP levels with kinetics similar to those of GroPIns-4-P formation, suggesting that GroPIns-4-P mediates this inhibitory effect. The hormone-induced formation of GroPIns-4-P was detected in several cell lines of various origin, suggesting that GroPIns-4-P is a novel intracellular messenger of the Ras pathway, possibly able to convey information from tyrosine kinase receptors to the cyclic AMP cascade.

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Citations

Jun 19, 2002·Biochimica Et Biophysica Acta·Daniela CordaChristopher P Berrie
Feb 18, 2003·Molecular Biology of the Cell·Raffaella ManciniDaniela Corda
Aug 12, 2009·Cellular and Molecular Life Sciences : CMLS·Daniela CordaStefania Mariggiò
Mar 4, 2011·Trends in Pharmacological Sciences·Ruth A Ross
Feb 5, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Roberto BuccioneDaniela Corda
Jan 21, 2012·Biochemical Society Transactions·Daniela CordaStefania Mariggiò
Jan 31, 2012·Biochimica Et Biophysica Acta·Roberto Piñeiro, Marco Falasca
Aug 30, 2008·Biochimica Et Biophysica Acta·Beatrice Maria FilippiDaniela Corda
Jun 11, 1999·The Journal of Biological Chemistry·M M MonickG W Hunninghake
Sep 14, 2001·Antioxidants & Redox Signaling·M R Kelley, S H Parsons
Oct 25, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Stefania MariggiòDaniela Corda
Oct 29, 2003·Antioxidants & Redox Signaling·Taku Sugawara, Pak H Chan
May 18, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M FujimuraP H Chan
Jan 10, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·P H Chan
Oct 31, 2003·Journal of Experimental Botany·Sookyung OhKyung-Hwan Han
Jul 14, 2005·Annual Review of Nutrition·Archana Jaiswal McEligotFrank L Meyskens
Jun 23, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Juan LuDaru Lu
Jun 6, 2021·Cell Communication and Signaling : CCS·Alessia VaroneDaniela Corda

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