Fast repair of dAMP hydroxyl radical adduct by verbascoside via electron transfer

Science in China. Series C, Life Sciences
Yimin ShiR Zheng

Abstract

DNA damaged by oxygen radicals has been implicated as a causative event in a number of degenerative diseases, including cancer and aging. So it is very important to look for ways in which either oxygen radicals are scavenged prior to DNA damage or damaged DNA is repaired to supplement the cells' inadequate repair capacity. The repair activity and its mechanism of verbascoside, isolated from Pedicularis species, towards dAMP-OH . was studied with pulse radiolytic technique. On pulse irradiation of nitrous oxide saturated 2 mmol/L dAMP aqueous solution containing verbascoside, the transient absorption spectrum of the hydroxyl adduct of dAMP decayed with the formation of that of the phenoxyl radical of verbascoside well under 100 microseconds after electron pulse irradiation. The result indicated that dAMP hydroxyl adducts can be repaired by verbascoside. The rate constants of the repair reaction was deduced to be 5.9 x 10(8) dm(3) * mol(-1) * s(-1). A deeper understanding of this new repair mechanism will undoubtedly help researchers explore new prevent and/or intervening medicine.

References

May 19, 1971·Nature: New Biology·J J van Hemmen
Jan 1, 1970·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·R L Willson
Jan 21, 1997·Proceedings of the National Academy of Sciences of the United States of America·F M Yakes, B Van Houten
Jun 1, 1997·Biulleten' eksperimental'noĭ biologii i meditsiny·I I TiurinaE Arrigoni-Martelli
Apr 1, 1996·Redox Report : Communications in Free Radical Research·N Pan, H Hori

❮ Previous
Next ❯

Citations

Sep 3, 2008·Science in China. Series C, Life Sciences·C ZhaoR Zheng
Sep 17, 2002·European Journal of Pharmacology·Guo-Qing ShengChang-Ling Li
Jun 6, 2003·Biochemical Pharmacology·Chenyang ZhaoRongliang Zheng
May 15, 2010·Chemical Society Reviews·Rongliang ZhengXiaorong Tan
Sep 5, 2014·Plastic Surgical Nursing : Official Journal of the American Society of Plastic and Reconstructive Surgical Nurses·Jennifer Wild

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.