PMID: 11320154Apr 26, 2001Paper

Fast repair of the radical cations of dCMP and poly C by quercetin and rutin

Mutagenesis
C ZhaoR Zheng

Abstract

The effects of quercetin and rutin on the repair of the radical cations of dCMP and poly C were studied using the technique of pulse radiolysis. The radical cations of dCMP and poly C were formed by the reaction of dCMP and poly C with SO( 4)(-). After pulse irradiation of nitrogen-saturated aqueous solutions containing dCMP, 20 mM K(2)S(2)O(8), 200 mM t-BuOH and either rutin or quercetin, the initially formed radical cation of dCMP, detected spectrophotometrically, rapidly decayed with the concurrent formation of the phenoxyl radical of rutin or quercetin within 8-40 micros. The repair efficiencies of the tested compounds towards the poly C radical cation were also determined using the same procedure. The results indicate that dCMP and poly C radical cations can be rapidly repaired by quercetin and rutin. The rate constants of the repair reactions were determined to be 4.3-8.8x10(8) M/s and 1.5-3.6x10(8) M/s for dCMP and poly C radical cations, respectively. Together with findings from our previous studies, the present results demonstrate that non-enzymatic fast repair may be a universal form of repair involving phenolic antioxidants.

Citations

Mar 23, 2005·Biochimica Et Biophysica Acta·Chenyang ZhaoBo-Tao Fan
Oct 4, 2011·Indian Journal of Clinical Biochemistry : IJCB·R Jayanthi, P Subash
May 15, 2010·Chemical Society Reviews·Rongliang ZhengXiaorong Tan
Sep 24, 2013·Food Chemistry·Augustin Cătălin MoţRadu Silaghi-Dumitrescu
Apr 21, 2009·Cell Biology International·Xiaorong TanRongliang Zheng
Dec 7, 2011·The Journal of Physical Chemistry. a·Alexis AspéeJuan C Scaiano
Dec 17, 2004·Alternatives to Laboratory Animals : ATLA·Fabiana AntognoniAnna Speranza
Jun 6, 2003·Biochemical Pharmacology·Chenyang ZhaoRongliang Zheng

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