Fast-scan Cyclic Voltammetry for the Characterization of Rapid Adenosine Release

Computational and Structural Biotechnology Journal
Michael D Nguyen, B Jill Venton

Abstract

Adenosine is a signaling molecule and downstream product of ATP that acts as a neuromodulator. Adenosine regulates physiological processes, such as neurotransmission and blood flow, on a time scale of minutes to hours. Recent developments in electrochemical techniques, including fast-scan cyclic voltammetry (FSCV), have allowed direct detection of adenosine with sub-second temporal resolution. FSCV studies have revealed a novel mode of rapid signaling that lasts only a few seconds. This rapid release of adenosine can be evoked by electrical or mechanical stimulations or it can be observed spontaneously without stimulation. Adenosine signaling on this time scale is activity dependent; however, the mode of release is not fully understood. Rapid adenosine release modulates oxygen levels and evoked dopamine release, indicating that adenosine may have a rapid modulatory role. In this review, we outline how FSCV can be used to detect adenosine release, compare FSCV with other techniques used to measure adenosine, and present an overview of adenosine signaling that has been characterized using FSCV. These studies point to a rapid mode of adenosine modulation, whose mechanism and function will continue to be characterized in the future.

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Citations

Mar 30, 2016·Pharmacology Research & Perspectives·Michael D NguyenB Jill Venton
Jun 18, 2016·Journal of Neurochemistry·Ying Wang, B Jill Venton
Jul 18, 2015·Biosensors & Bioelectronics·Jason M HinzmanJed A Hartings
Feb 15, 2018·Journal of Neuroengineering and Rehabilitation·Scott D AdamsMichael Berk
Jan 11, 2020·The Analyst·B Jill Venton, Qun Cao
Jan 11, 2020·The Analyst·Pumidech Puthongkham, B Jill Venton
Feb 11, 2020·Journal of Neurochemistry·Jason R BorgusB Jill Venton
Aug 2, 2017·Neural Regeneration Research·Kunihiko Yamashiro, Mitsuhiro Morita
Jul 30, 2020·Analytical Methods : Advancing Methods and Applications·Yangguang OuParastoo Hashemi
Dec 18, 2020·Frontiers in Bioengineering and Biotechnology·Elisa CastagnolaXinyan Tracy Cui
Jan 15, 2021·Biochemical Pharmacology·Nicholas Dale
Feb 7, 2017·Journal of Electroanalytical Chemistry·Samuel S Hinman, Quan Cheng
May 8, 2021·Analytical Methods : Advancing Methods and Applications·Yuxin LiAshley E Ross
Jun 8, 2021·Brain and Language·Ariana Z TurkShahriar SheikhBahaei
Jul 15, 2021·Analytical and Bioanalytical Chemistry·Harmain Rafi, Alexander G Zestos
Jan 11, 2017·ACS Chemical Neuroscience·Michael D NguyenB Jill Venton
Feb 16, 2017·ACS Chemical Neuroscience·Ryan P BormanB Jill Venton
Feb 8, 2018·ACS Chemical Neuroscience·Mimi ShinB Jill Venton
Aug 18, 2021·Journal of Neural Engineering·Mamta DeviSwati Sharma
Dec 11, 2021·Faraday Discussions·Qun CaoB Jill Venton

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Methods Mentioned

BETA
biosensors
biosensor

Software Mentioned

FSCV

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