Fast self-assembly kinetics of quantum dots and a dendrimeric peptide ligand

Langmuir : the ACS Journal of Surfaces and Colloids
Jianhao WangJiang Xia

Abstract

Engineered peptide ligands with exceptionally high affinity for metal can self-assemble with nanoparticles in biological fluids. A high-affinity dendrimeric peptide ligand for CdSe-ZnS quantum dots (QDs) exhibited very fast association kinetics with QDs and reached equilibrium within 2 s. Here, we have combined a droplet-based microfluidic device with fluorescence detection based on Förster resonance energy transfer (FRET) to provide subsecond resolution in dissecting this fast self-assembly kinetics in solution. This work represents the first application of microfluidic devices to ligand-particle assembly for the measurement of fast assembly kinetics in solution.

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Citations

Feb 6, 2013·Bioconjugate Chemistry·Kelly Boeneman GemmillIgor L Medintz
Sep 26, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Jianpeng WangJiang Xia
Nov 13, 2015·Applied Optics·Christopher M SpillmannIgor L Medintz
Aug 30, 2012·Proteomics·Hui-Fen WuNazim Hasan
Oct 28, 2018·Journal of Separation Science·Jianhao WangYong-Qiang Li
Sep 13, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Yao LuJiang Xia

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