Fast temporal response fiber-optic chemical sensors based on the photodeposition of micrometer-scale polymer arrays

Analytical Chemistry
B G Healey, David R Walt

Abstract

Fiber-optic chemical sensor microarrays for the detection of pH and O2 have been developed with subsecond response times. Sensor microarrays are fabricated by the covalent immobilization (pH sensor arrays) or the physical entrapment (O2 sensor arrays) of fluorescent indicators in photodeposited polymer matrices on optical imaging fibers. Polymer microarrays are comprised of thousands of individual elements photodeposited as hemispheres such that each element of the sensor array is coupled directly to a discrete optical element of the imaging fiber and is not in contact with other neighboring elements. Because of the hemispherical shape and the individuality of the array elements, diffusion of analyte to the sensor elements is dominated by radial diffusion, resulting in a rapid response time. pH-sensitive arrays based on fluorescein respond to a 1.5-unit pH change within 300 ms, while the O2-sensitive arrays respond to O2 changes within 200 ms (90% of steady state response).

References

Dec 15, 1987·Analytical Chemistry·T J KulpD R Walt
Sep 1, 1995·Analytical Chemistry·K S BronkD R Walt
Aug 1, 1995·Analytical Chemistry·Z Rosenzweig, R Kopelman
Feb 1, 1988·Talanta·C MunkholmF P Milanovich

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Citations

Sep 28, 1999·The Journal of Emergency Medicine·J C Hodge
May 23, 2002·Current Opinion in Chemical Biology·Kit S Lam, Manat Renil
Apr 28, 2005·Biosensors & Bioelectronics·George S Wilson, Raeann Gifford
Oct 19, 2005·Biosensors & Bioelectronics·J Chance CarterBill W Colston
Sep 18, 1999·Analytical Chemistry·W TanM T Miller
Oct 5, 2013·Chemical Society Reviews·Jon R AskimKenneth S Suslick
Apr 30, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Mary B Chan-ParkJung-Hoon Chun
Dec 26, 2001·Chemical Reviews·K J AlbertD R Walt
Jun 14, 2001·Analytical Chemistry·D D BernhardP Pantano
Feb 26, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Joseph P Labukas, Gregory S Ferguson
Nov 5, 2020·Chemical Reviews·Andreas SteineggerSergey M Borisov
Apr 14, 2005·Journal of the American Chemical Society·Nathaniel T Greene, Ken D Shimizu

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