Fast time-resolved NMR with non-uniform sampling

Progress in Nuclear Magnetic Resonance Spectroscopy
Dariusz GołowiczKrzysztof Kazimierczuk

Abstract

NMR spectroscopy is a versatile tool for studying time-dependent processes: chemical reactions, phase transitions or macromolecular structure changes. However, time-resolved NMR is usually based on the simplest among available techniques - one-dimensional spectra serving as "snapshots" of the studied process. One of the reasons is that multidimensional experiments are very time-expensive due to costly sampling of evolution time space. In this review we summarize efforts to alleviate the problem of limited applicability of multidimensional NMR in time-resolved studies. We focus on techniques based on sparse or non-uniform sampling (NUS), which lead to experimental time reduction by omitting a significant part of the data during measurement and reconstructing it mathematically, adopting certain assumptions about the spectrum. NUS spectra are faster to acquire than conventional ones and thus better suited to the role of "snapshots", but still suffer from non-stationarity of the signal i.e. amplitude and frequency variations within a dataset. We discuss in detail how these instabilities affect the spectra, and what are the optimal ways of sampling the non-stationary FID signal. Finally, we discuss related areas of NMR where serial ...Continue Reading

Citations

Sep 29, 2020·Chemistry : a European Journal·Alexandra ShchukinaKrzysztof Kazimierczuk
Oct 6, 2020·Magnetic Resonance in Chemistry : MRC·Dariusz GołowiczKrzysztof Kazimierczuk
Sep 7, 2020·Magnetic Resonance in Chemistry : MRC·Ellen SteimersDaniel J Holland
Jul 12, 2021·Journal of Magnetic Resonance·Jonathan R J YongTim D W Claridge
Jun 20, 2020·Analytical Chemistry·Mateusz UrbańczykVille-Veikko Telkki
Jun 5, 2020·The Journal of Physical Chemistry. a·Manpreet KaurLeonard J Mueller

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