Fast-to-slow conversion following chronic low-frequency activation of medial gastrocnemius muscle in cats. I. Muscle and motor unit properties

Journal of Neurophysiology
T GordonJ B Munson

Abstract

This study of cat medial gastrocnemius (MG) muscle and motor unit (MU) properties tests the hypothesis that the normal ranges of MU contractile force, endurance, and speed are directly associated with the amount of neuromuscular activity normally experienced by each MU. We synchronously activated all MUs in the MG muscle with the same activity (20 Hz in a 50% duty cycle) and asked whether conversion of whole muscle contractile properties is associated with loss of the normal heterogeneity in MU properties. Chronically implanted cuff electrodes on the nerve to MG muscle were used for 24-h/day stimulation and for monitoring progressive changes in contractile force, endurance, and speed by periodic recording of maximal isometric twitch and tetanic contractions under halothane anesthesia. Chronic low-frequency stimulation slowed muscle contractions and made them weaker, and increased muscle endurance. The most rapid and least variable response to stimulation was a decline in force output of the muscle and constituent MUs. Fatigue resistance increased more slowly, whereas the increase in time to peak force varied most widely between animals and occurred with a longer time course than either force or endurance. Changes in contractile...Continue Reading

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Citations

May 12, 2006·Pflügers Archiv : European journal of physiology·Maria GalloCharles T Putman
Jan 22, 2009·Human Molecular Genetics·Elena KudryashovaMelissa J Spencer
Feb 9, 2012·The Journal of Physiology·Inge Zijdewind, Christine K Thomas
Oct 14, 2014·Frontiers in Human Neuroscience·Chad Lorenz, Kelvin E Jones
Apr 11, 2003·Journal of Neurophysiology·David Gonzalez-ForeroAngel M Pastor
Nov 4, 2004·Canadian Journal of Physiology and Pharmacology·Tessa GordonRichard B Stein
Aug 2, 2013·Acta Physiologica·C K ThomasI Zijdewind
Apr 14, 2006·Journal of Neurophysiology·C K Häger-RossC K Thomas
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Jul 31, 2013·Topics in Stroke Rehabilitation·Barbara M Doucet, Lisa Griffin
Nov 21, 2020·International Journal of Molecular Sciences·Tessa Gordon
May 2, 2006·Progress in Neurobiology·Jonathan R Wolpaw, Jonathan S Carp

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