Fast-to-slow conversion following chronic low-frequency activation of medial gastrocnemius muscle in cats. II. Motoneuron properties

Journal of Neurophysiology
J B MunsonT Gordon

Abstract

Chronic stimulation (for 2-3 mo) of the medial gastrocnemius (MG) muscle nerve by indwelling electrodes renders the normally heterogeneous MG muscle mechanically and histochemically slow (type SO). We tested the hypothesis that motoneurons of MG muscle thus made type SO by chronic stimulation would also convert to slow phenotype. Properties of all single muscle units became homogeneously type SO (slowly contracting, nonfatiguing, nonsagging contraction during tetanic activation). Motoneuron electrical properties were also modified in the direction of type S, fatigue-resistant motor units. Two separate populations were identified (on the basis of afterhyperpolarization, rheobase, and input resistance) that likely correspond to motoneurons that had been fast (type F) or type S before stimulation. Type F motoneurons, although modified by chronic stimulation, were not converted to the type S phenotype, despite apparent complete conversion of their muscle units to the slow oxidative type (type SO). Muscle units of the former type F motor units were faster and/or more powerful than those of the former type S motor units, indicating some intrinsic regulation of motor unit properties. Experiments in which chronic stimulation was applie...Continue Reading

References

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Citations

Aug 15, 2002·American Journal of Physiology. Cell Physiology·Kambiz MousaviDavid J Parry
Apr 11, 2003·Journal of Neurophysiology·David Gonzalez-ForeroAngel M Pastor
Oct 9, 2009·Muscle & Nerve·Daniel I Ogborn, Phillip F Gardiner
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Feb 13, 2002·The Journal of Orthopaedic and Sports Physical Therapy·Richard K Shields
Nov 19, 2003·The European Journal of Neuroscience·Magda SimonGiorgio Terenghi
Apr 15, 2006·The Journal of Physiology·Duane C ButtonPhillip F Gardiner
Sep 1, 2005·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·Phillip GardinerBruno Cormery
Nov 4, 2004·Canadian Journal of Physiology and Pharmacology·Tessa GordonRichard B Stein
Oct 3, 2001·Physiological Reviews·S C Gandevia
Apr 14, 2006·Journal of Neurophysiology·C K Häger-RossC K Thomas
Nov 12, 2009·Brain : a Journal of Neurology·Christine K ThomasCliff S Klein
Jan 28, 2003·Muscle & Nerve·Eric Beaumont, Phillip F Gardiner
Nov 18, 2016·Journal of Neurophysiology·Christine K ThomasCliff S Klein
Sep 22, 2009·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Sandra C WebberPhillip F Gardiner
Nov 21, 2020·International Journal of Molecular Sciences·Tessa Gordon
Nov 9, 2004·Experimental Neurology·Grant A Robinson, Roger D Madison
Dec 14, 2004·Experimental Neurology·Prodip BoseFloyd J Thompson
Feb 9, 2005·Experimental Neurology·Grant A Robinson, Roger D Madison
Dec 13, 2006·Brain Research·Farzaneh Ganji, Gila Behzadi

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