Apr 11, 2020

Testosterone use in female mice does not impair fertilizability of eggs: Implications for the fertility care of transgender males

BioRxiv : the Preprint Server for Biology
C. B. BartelsLisa M Mehlmann

Abstract

STUDY QUESTION: Does testosterone use in females affect reproductive potential, particularly with regard to the production of fertilizable gametes? SUMMARY ANSWER: Testosterone cypionate injections given to post-pubertal female mice caused virilization and ovaries were smaller than control ovaries, but ovaries were still responsive to hormonal stimulation and produced fertilizable eggs when superovulated. WHAT IS KNOWN ALREADY: Studies to examine the effects of testosterone on reproductive potential in transgender males are lacking. Recently, a model was developed that simulates many aspects of testosterone use in transgender males in order to look at reproductive effects of testosterone in female mice. This study found masculinizing effects on the mice but did not find significant deficits on the number of ovarian follicles; however, effects of testosterone use on ovarian stimulation and fertilizability of oocytes were not investigated. STUDY DESIGN, SIZE, DURATION: A total of 66, 6-week-old Hsd:NSA(CF-1) female mice and 6 Hsd:ICR (CD-1) mice were used for this study. Mice were injected subcutaneously with 400 g testosterone cypionate or sesame oil once a week for 6 weeks and were either sacrificed a week after the 6th injecti...Continue Reading

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Mentioned in this Paper

Calcium [EPC]
Neuropil
Calcium
Anatomic Structures
Neurons
Brain
Drosophila
Response to Stimulus Physiology
Microscopy
Literature

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