Abstract
The neurons in the hypothalamus regulate food intake and energy metabolism on reception of systemic energy states. Accumulating evidences have indicated that synaptic transmission on the hypothalamic neurons is modulated by the metabolic condition related to fasted/fed states, and that this modulation of synaptic plasticity plays a role in regulation of feeding. It has been shown that oxytocin (Oxt) neurons in the paraventricular nucleus (PVN) of the hypothalamus sense and integrate various peripheral and central signals and thereby induce satiety. However, whether metabolic conditions regulate the synaptic transmission on Oxt neurons in PVN remains unclear. The present study examined whether the fasted/fed states regulate synaptic transmission on Oxt neurons in PVN. The miniature excitatory postsynaptic currents (mEPSCs) onto Oxt neurons in PVN were increased under ad lib fed condition compared to 24h fasted condition. Furthermore, the NMDA receptor-mediated EPSC on Oxt neurons was increased under fed, compared to fasted, condition. In Oxt neurons, dynein light chain 2 (DYNLL2), a protein suggested to be implicated in the NMDA receptor trafficking to the postsynaptic site, was increased under fed, compared to fasted, condition...Continue Reading
References
Jan 1, 1989·Peptides·R ArlettiA Bertolini
Dec 1, 1988·Neuroendocrinology·L M FlanaganE M Stricker
Jan 1, 1997·Pharmacology, Biochemistry, and Behavior·G A Burns, R C Ritter
Mar 15, 1997·The Journal of Physiology·J S Bains, A V Ferguson
Sep 2, 1998·The Journal of Comparative Neurology·L Rinaman
Feb 27, 1999·Current Opinion in Biotechnology·J E Celis, P Gromov
Apr 6, 2004·Science·Shirly PintoTamas L Horvath
Nov 18, 2005·Neuropharmacology·Maria Rosaria MelisAntonio Argiolas
May 7, 2008·Journal of Proteome Research·Misato HiranoYoshinori Masuo
Nov 21, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yi-Chun Loraine TungGiles S H Yeo
Nov 4, 2009·Cell Metabolism·Yuko MaejimaToshihiko Yada
Aug 4, 2010·Proceedings of the National Academy of Sciences of the United States of America·Tamas L HorvathMatthias H Tschöp
May 10, 2011·Physiology & Behavior·B G StanleyT Kee
Aug 11, 2011·American Journal of Physiology. Endocrinology and Metabolism·Guo Zhang, Dongsheng Cai
Sep 20, 2011·Cell·Yunlei YangScott M Sternson
Feb 14, 2012·Neuron·Tiemin LiuBradford B Lowell
Feb 14, 2012·Journal of Cell Science·Enora MoutinJulie Perroy
Apr 3, 2012·Biochemical and Biophysical Research Communications·Darambazar GantulgaToshihiko Yada
Aug 31, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alexandre BenaniLuc Pénicaud
Aug 22, 2013·Proceedings of the National Academy of Sciences of the United States of America·Qi WuRichard D Palmiter
Sep 26, 2013·Peptides·Pawel K OlszewskiAllen S Levine
May 9, 2014·Physiology & Behavior·Juan Gabriel Tejas-JuárezRodrigo Erick Escartín-Pérez
Jun 2, 2014·Nature Neuroscience·Jae Geun KimTamas L Horvath
Jun 19, 2014·Journal of Cell Science·Enora MoutinJulie Perroy
Sep 16, 2014·Neuroscience Letters·Jun-ichi OhkuboYoichi Ueta
Nov 15, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Carlos A Campos, Robert C Ritter
Dec 24, 2014·Biochemical and Biophysical Research Communications·Gantulga DarambazarToshihiko Yada
Citations
Oct 21, 2016·Journal of Neurochemistry·Olalekan M OgundeleJoseph Francis
Aug 10, 2016·Scientific Reports·Shigetomo SuyamaToshihiko Yada
Nov 26, 2016·Physiological Reports·Jeffrey S MartinMichael D Roberts
Aug 2, 2017·ELife·Shigetomo SuyamaTamas L Horvath
Mar 19, 2020·Frontiers in Psychiatry·Marta Tyszkiewicz-NwaforAgnieszka Słopien