PMID: 9541867May 16, 1998Paper

Faster multipoint linkage analysis using Fourier transforms

Journal of Computational Biology : a Journal of Computational Molecular Cell Biology
L Kruglyak, E S Lander

Abstract

Genetic linkage analysis of human pedigrees using many linked markers simultaneously is a difficult computational problem. We have previously described an approach to this problem that uses hidden Markov models (HMMs) and is quite efficient for pedigrees of moderate size. Here, we describe a new, faster algorithm for the key step in the HMM calculation. The algorithm employs a fast Fourier transform on the group of pedigree inheritance patterns. It substantially improves the overall performance of the software package GENEHUNTER for performing linkage analysis. The Fourier representation opens up new research directions for pedigree analysis.

References

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Citations

Dec 22, 1999·Genetic Epidemiology·D CurtisP C Sham
Dec 22, 1999·Genetic Epidemiology·G A DarlingtonC Toma
Dec 13, 2005·Behavior Genetics·Steven BuyskePaul Manowitz
Apr 28, 2004·Molecular Genetics and Metabolism·Yelena BykhovskayaNathan Fischel-Ghodsian
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